Trastuzumab deruxtecan in advanced breast cancer patients with brain metastases or leptomeningeal metastases

• Published in: Cancer pathogenesis and therapy
• Main Authors: Liu, Jinsong, Quan, Liuliu, Sang, Die, Guan, Xiao, Dou, Min, Yue, Jian, Yuan, Peng
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2025

•Trastuzumab deruxtecan showed superior intracranial overall response rate (ORR) and median progression-free survival (mPFS) than controls in both stable and active brain metastases.•DEBBRAH, TUXEDO-1, and DESTINY-Breast 12 confirm durable intracranial activity in brain metastases with trastuzumab d...