Polyanhydrides: Synthesis, Properties, and Applications

This review focusses on polyanhydrides, a fascinating class of degradable polymers that have been used in and investigated for many bio-related applications because of their degradability and capacity to undergo surface erosion. This latter phenomenon is driven by hydrolysis of the anhydride moietie...

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Published inAustralian journal of chemistry Vol. 69; no. 11; pp. 1223 - 1239
Main Authors Poetz, Katie L., Shipp, Devon A.
Format Journal Article
LanguageEnglish
Published 01.01.2016
Subjects
Degradation
Erosion
Hydrolysis
Nanostructure
Polyanhydrides
Polymerization
Polymers
Synthesis
Online AccessGet full text
ISSN0004-9425
1445-0038
DOI10.1071/CH16144

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Abstract This review focusses on polyanhydrides, a fascinating class of degradable polymers that have been used in and investigated for many bio-related applications because of their degradability and capacity to undergo surface erosion. This latter phenomenon is driven by hydrolysis of the anhydride moieties at the surface and high hydrophobicity of the polymer such that degradation and mass loss (erosion) occur before water can penetrate deep within the bulk of the polymer. As such, when surface-eroding polymers are used as therapeutic delivery vehicles, the rate of delivery is often controlled by the rate of polymer erosion, providing predictable and controlled release rates that are often zero-order. These desirable attributes are heavily influenced by polymer composition and morphology, and therefore also monomer structure and polymerization method. This review examines approaches for polyanhydride synthesis, discusses their general thermomechanical properties, surveys their hydrolysis and degradation processes along with their biocompatibility, and looks at recent developments and uses of polyanhydrides in drug delivery, stimuli-responsive materials, and novel nanotechnologies.
AbstractList This review focusses on polyanhydrides, a fascinating class of degradable polymers that have been used in and investigated for many bio-related applications because of their degradability and capacity to undergo surface erosion. This latter phenomenon is driven by hydrolysis of the anhydride moieties at the surface and high hydrophobicity of the polymer such that degradation and mass loss (erosion) occur before water can penetrate deep within the bulk of the polymer. As such, when surface-eroding polymers are used as therapeutic delivery vehicles, the rate of delivery is often controlled by the rate of polymer erosion, providing predictable and controlled release rates that are often zero-order. These desirable attributes are heavily influenced by polymer composition and morphology, and therefore also monomer structure and polymerization method. This review examines approaches for polyanhydride synthesis, discusses their general thermomechanical properties, surveys their hydrolysis and degradation processes along with their biocompatibility, and looks at recent developments and uses of polyanhydrides in drug delivery, stimuli-responsive materials, and novel nanotechnologies.
Author Poetz, Katie L.
Shipp, Devon A.
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Cites_doi 10.1002/app.37708
10.1016/S0142-9612(03)00563-5
10.1016/j.biomaterials.2013.12.025
10.1021/ma102287v
10.1016/j.jconrel.2012.07.033
10.1002/macp.1962.020550114
10.1016/0168-3659(87)90033-2
10.1016/S0939-6411(02)00191-1
10.1016/S0142-9612(02)00170-9
10.1016/S0142-9612(98)00019-2
10.1016/j.biomaterials.2006.08.047
10.1038/386410a0
10.1517/17425247.5.8.889
10.3109/02652048.2014.973073
10.1002/jbm.a.32288
10.1002/jor.1100140315
10.1016/j.jconrel.2013.10.012
10.1038/nrd1414
10.1016/S0169-409X(02)00228-4
10.1016/j.biomaterials.2008.12.002
10.1016/j.jconrel.2004.08.006
10.1002/(SICI)1097-4636(19990605)45:3<258::AID-JBM14>3.0.CO;2-W
10.1021/ja01343a051
10.1002/aic.690481221
10.1002/jbm.a.33049
10.1016/S0142-9612(98)00108-2
10.1016/S0140-6736(95)90755-6
10.1002/macp.1962.020560103
10.1081/DDC-120006422
10.1016/j.ijpharm.2007.06.039
10.1002/pola.10073
10.1038/367258a0
10.1016/S0142-9612(02)00181-3
10.1021/ja01347a066
10.1039/b901979k
10.1039/b615954k
10.1002/macp.1962.020560102
10.1021/ja01942a009
10.1002/pola.1993.080310523
10.1016/S0142-9612(00)00073-9
10.1016/j.jconrel.2013.06.024
10.1002/adhm.201200181
10.1039/C5PY00843C
10.1002/jbm.a.20101
10.1002/(SICI)1097-4636(199824)43:4<374::AID-JBM5>3.0.CO;2-5
10.1021/bm5017282
10.1038/6152
10.1002/pola.1991.080290413
10.1016/j.biomaterials.2010.06.011
10.1002/pola.10651
10.1002/jbm.820280314
10.1002/jbm.b.31478
10.1080/00222338508063294
10.1039/c0gc00773k
10.1016/S0142-9612(98)00109-4
10.1039/C5BM00051C
10.1002/pola.10697
10.1016/j.biomaterials.2008.01.013
10.1016/j.ces.2014.08.015
10.1002/jbm.820200106
10.1016/S0169-409X(02)00051-0
10.1002/jbm.a.30510
10.1016/j.actbio.2013.06.006
10.1007/s00289-006-0561-z
10.1016/S0142-9612(96)00151-2
10.1002/marc.201100155
10.1021/ma00185a008
10.1016/j.polymer.2004.03.035
10.1002/jbm.820281212
10.1021/ar9800993
10.1021/ma00068a006
10.1080/00222346808212871
10.1021/ma00170a001
10.1002/1097-4636(20000905)51:3<352::AID-JBM8>3.0.CO;2-C
10.1039/b911557a
10.1021/bm401715z
10.1023/A:1018995913972
10.1021/ar00034a004
10.1002/(SICI)1097-4636(1999)48:3<322::AID-JBM17>3.0.CO;2-U
10.1016/0142-9612(96)85755-3
10.1039/C5CP00473J
10.1016/j.jconrel.2004.12.021
10.1021/ma961627y
10.1021/bm3018998
10.1016/S0142-9612(03)00219-9
10.1016/j.jconrel.2004.03.001
10.1016/j.biomaterials.2013.02.071
10.1021/ma00027a003
10.1021/ie500679u
10.1021/mp2004059
10.1002/pola.10951
10.1002/jbm.820190806
10.1002/jbm.820291010
10.1021/acsmacrolett.5b00854
10.1021/ma00215a003
10.1002/adma.200904447
10.1080/15583724.2012.752745
10.1002/macp.1959.020320101
10.1016/S0169-409X(02)00052-2
10.1021/ja00167a045
10.1016/S0168-3659(97)00054-0
10.1016/j.reactfunctpolym.2012.07.014
10.1073/pnas.90.2.552
10.1016/j.actbio.2012.11.001
10.1002/jps.10446
10.1016/j.addr.2010.10.008
10.1021/bm500420q
10.1002/jbm.a.34949
10.1021/ja01343a050
10.1002/jbm.a.35086
10.1021/bm500927r
10.1002/marc.200900059
10.1021/bm000081r
10.1021/ma047661r
10.1021/acs.biomac.5b00280
10.1021/ma00195a018
10.1002/app.33546
10.1002/jbm.820241105
10.1016/j.actbio.2011.03.023
10.1016/j.biomaterials.2007.08.022
10.1016/S0168-3659(99)00071-1
10.1016/j.nantod.2012.08.005
10.1021/bm500303a
10.1002/marc.201300323
10.1002/jbm.a.35630
10.1177/0883911514528410
10.1021/ja01373a053
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References Domb (CH16144R24) 1989; 22
Yoda (CH16144R11) 1962; 55
Chandorkar (CH16144R80) 2014; 15
Torres (CH16144R91) 2011; 7
Poetz (CH16144R109) 2014; 15
Stebbins (CH16144R47) 2015; 3
Subramanyam (CH16144R20) 1985; 22
Domb (CH16144R42) 1991; 29
Jia (CH16144R86) 2013; 172
Yoda (CH16144R9) 1959; 32
Prudencio (CH16144R78) 2009; 30
Thanos (CH16144R118) 2003; 92
Teomim (CH16144R34) 2001; 2
Masters (CH16144R85) 1993; 10
Yoda (CH16144R12) 1962; 56
Brem (CH16144R2) 1995; 345
Kipper (CH16144R64) 2005; 38
Wang (CH16144R131) 2014; 35
Krasko (CH16144R45) 2003; 41
Liang (CH16144R49) 2013; 127
Yakacki (CH16144R134) 2013; 53
Rutherglen (CH16144R43) 2010; 43
Lopac (CH16144R121) 2009; 91B
Lluch (CH16144R37) 2011; 32
Domb (CH16144R38) 1992; 25
Teomim (CH16144R32) 1999; 45
G pferich (CH16144R52) 1993; 26
Laurencin (CH16144R97) 1990; 24
Leong (CH16144R19) 1987; 20
Lai (CH16144R130) 2012; 72
Cai (CH16144R82) 2003; 55
Poetz (CH16144R30) 2015; 16
Erdmann (CH16144R48) 2000; 21
Joshi (CH16144R90) 2013; 9
Attawia (CH16144R98) 1999; 48
Mathiowitz (CH16144R115) 1997; 386
Delgado-Rivera (CH16144R122) 2014; 102
Weiner (CH16144R28) 2008; 29
Burkoth (CH16144R107) 2000; 51
Bucher (CH16144R4) 1909; 31
Anseth (CH16144R22) 1999; 17
Yoda (CH16144R10) 1962; 56
Rogers (CH16144R70) 2014; 15
Huntimer (CH16144R105) 2013; 2
Torres (CH16144R104) 2007; 28
G pferich (CH16144R58) 1996; 17
Quick (CH16144R92) 2004; 97
Cheng (CH16144R41) 2004; 45
Acharya (CH16144R125) 2011; 63
Shieh (CH16144R33) 1994; 28
Carbone-Howell (CH16144R75) 2014; 15
Attawia (CH16144R100) 1996; 14
Carothers (CH16144R7) 1932; 54
Jain (CH16144R66) 2005; 103
Panyam (CH16144R126) 2003; 55
Ibim (CH16144R101) 1998; 43
Shikanov (CH16144R46) 2004; 69A
Langer (CH16144R55) 1993; 26
Haughney (CH16144R94) 2013; 9
Hill (CH16144R5) 1930; 52
Li (CH16144R50) 2003; 41
G pferich (CH16144R60) 1997; 18
G pferich (CH16144R13) 2002; 54
Hoyle (CH16144R44) 2010; 39
Teomim (CH16144R84) 1999; 60
Tarcha (CH16144R23) 2001; 39
Katti (CH16144R95) 2002; 54
Griffin (CH16144R68) 2011; 97A
Domb (CH16144R31) 1993; 31
Rosario-Melendez (CH16144R79) 2012; 162
Kipper (CH16144R120) 2002; 23
Leong (CH16144R16) 1985; 19
Torres (CH16144R103) 2006; 76A
Leach (CH16144R114) 1998; 19
Deng (CH16144R127) 2012; 7
Wada (CH16144R72) 2013; 171
Guo (CH16144R129) 2013; 34
Determan (CH16144R119) 2004; 100
Behl (CH16144R132) 2010; 22
Carrillo-Conde (CH16144R93) 2015; 125
Helminen (CH16144R51) 2003; 41
Sun (CH16144R128) 2010; 31
Lawton (CH16144R26) 2016; 5
Wu (CH16144R57) 1994; 28
Cottler (CH16144R40) 1967; 63
Mathiowitz (CH16144R110) 1987; 5
Attawia (CH16144R99) 1995; 29
Hill (CH16144R6) 1932; 54
Leong (CH16144R96) 1986; 20
Santos (CH16144R117) 2003; 24
Leach (CH16144R113) 1998; 19
Lee (CH16144R69) 2016; 104
Schmeltzer (CH16144R71) 2006; 57
Prudencio (CH16144R73) 2014; 29
G pferich (CH16144R59) 1997; 30
Koenig (CH16144R54) 1968; 2
Ouimet (CH16144R76) 2013; 14
T r nc (CH16144R36) 2011; 13
Ibim (CH16144R102) 1998; 19
Domb (CH16144R18) 1988; 21
Natarajan (CH16144R35) 2014; 53
Domanskyi (CH16144R65) 2015; 17
Shipp (CH16144R29) 2009
Petersen (CH16144R88) 2012; 9
Mathiowitz (CH16144R39) 1990; 23
Larobina (CH16144R63) 2002; 48
Bagherifam (CH16144R87) 2015; 32
Chandorkar (CH16144R81) 2015; 16
Poetz (CH16144R124) 2015; 6
Tamada (CH16144R53) 1993; 90
Ouimet (CH16144R77) 2013; 34
Weiner (CH16144R27) 2007; 28
Lesniak (CH16144R1) 2004; 3
Tian (CH16144R83) 2002; 28
Shastri (CH16144R106) 2004; 25
Hurd (CH16144R25) 1932; 54
Pekarek (CH16144R116) 1994; 367
Staubli (CH16144R21) 1990; 112
Liu (CH16144R133) 2007; 17
von Burkersroda (CH16144R61) 2002; 23
Mohammed (CH16144R108) 2016
Jain (CH16144R67) 2008; 5
Conix (CH16144R8) 1958; 29
Chickering (CH16144R111) 1997; 48
Furtado (CH16144R112) 2008; 347
Yu (CH16144R123) 2011; 121
Rothstein (CH16144R62) 2009; 30
Langer (CH16144R56) 2000; 33
Johnson (CH16144R74) 2009; 91A
Ross (CH16144R89) 2014; 102
References_xml – volume: 127
  start-page: 3948
  year: 2013
  ident: CH16144R49
  publication-title: J. Appl. Polym. Sci.
  doi: 10.1002/app.37708
– volume: 25
  start-page: 715
  year: 2004
  ident: CH16144R106
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(03)00563-5
– volume: 35
  start-page: 3080
  year: 2014
  ident: CH16144R131
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.12.025
– volume: 43
  start-page: 10297
  year: 2010
  ident: CH16144R43
  publication-title: Macromolecules
  doi: 10.1021/ma102287v
– volume: 162
  start-page: 538
  year: 2012
  ident: CH16144R79
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2012.07.033
– volume: 55
  start-page: 174
  year: 1962
  ident: CH16144R11
  publication-title: Makromol. Chem.
  doi: 10.1002/macp.1962.020550114
– volume: 5
  start-page: 13
  year: 1987
  ident: CH16144R110
  publication-title: J. Control. Release
  doi: 10.1016/0168-3659(87)90033-2
– volume: 55
  start-page: 203
  year: 2003
  ident: CH16144R82
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/S0939-6411(02)00191-1
– volume: 23
  start-page: 4221
  year: 2002
  ident: CH16144R61
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(02)00170-9
– volume: 19
  start-page: 941
  year: 1998
  ident: CH16144R102
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(98)00019-2
– volume: 28
  start-page: 108
  year: 2007
  ident: CH16144R104
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2006.08.047
– volume: 386
  start-page: 410
  year: 1997
  ident: CH16144R115
  publication-title: Nature
  doi: 10.1038/386410a0
– volume: 5
  start-page: 889
  year: 2008
  ident: CH16144R67
  publication-title: Expert Opin. Drug Deliv.
  doi: 10.1517/17425247.5.8.889
– volume: 32
  start-page: 166
  year: 2015
  ident: CH16144R87
  publication-title: J. Microencapsul.
  doi: 10.3109/02652048.2014.973073
– volume: 91A
  start-page: 671
  year: 2009
  ident: CH16144R74
  publication-title: J. Biomed. Mater. Res. Part A
  doi: 10.1002/jbm.a.32288
– volume: 14
  start-page: 445
  year: 1996
  ident: CH16144R100
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.1100140315
– volume: 172
  start-page: 1020
  year: 2013
  ident: CH16144R86
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2013.10.012
– volume: 3
  start-page: 499
  year: 2004
  ident: CH16144R1
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd1414
– volume: 55
  start-page: 329
  year: 2003
  ident: CH16144R126
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(02)00228-4
– volume: 30
  start-page: 1657
  year: 2009
  ident: CH16144R62
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2008.12.002
– volume: 100
  start-page: 97
  year: 2004
  ident: CH16144R119
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2004.08.006
– volume: 45
  start-page: 258
  year: 1999
  ident: CH16144R32
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/(SICI)1097-4636(19990605)45:3<258::AID-JBM14>3.0.CO;2-W
– volume: 54
  start-page: 1579
  year: 1932
  ident: CH16144R7
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja01343a051
– volume: 48
  start-page: 2960
  year: 2002
  ident: CH16144R63
  publication-title: AIChE J.
  doi: 10.1002/aic.690481221
– volume: 97A
  start-page: 230
  year: 2011
  ident: CH16144R68
  publication-title: J. Biomed. Mater. Res. Part A
  doi: 10.1002/jbm.a.33049
– volume: 19
  start-page: 1973
  year: 1998
  ident: CH16144R113
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(98)00108-2
– volume: 345
  start-page: 1008
  year: 1995
  ident: CH16144R2
  publication-title: Lancet
  doi: 10.1016/S0140-6736(95)90755-6
– volume: 56
  start-page: 36
  year: 1962
  ident: CH16144R10
  publication-title: Makromol. Chem.
  doi: 10.1002/macp.1962.020560103
– volume: 28
  start-page: 897
  year: 2002
  ident: CH16144R83
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1081/DDC-120006422
– volume: 347
  start-page: 149
  year: 2008
  ident: CH16144R112
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2007.06.039
– volume: 39
  start-page: 4189
  year: 2001
  ident: CH16144R23
  publication-title: J. Polym. Sci. Part A: Polym. Chem.
  doi: 10.1002/pola.10073
– volume: 367
  start-page: 258
  year: 1994
  ident: CH16144R116
  publication-title: Nature
  doi: 10.1038/367258a0
– volume: 23
  start-page: 4405
  year: 2002
  ident: CH16144R120
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(02)00181-3
– volume: 54
  start-page: 3427
  year: 1932
  ident: CH16144R25
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja01347a066
– volume: 39
  start-page: 1355
  year: 2010
  ident: CH16144R44
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/b901979k
– volume: 17
  start-page: 1543
  year: 2007
  ident: CH16144R133
  publication-title: J. Mater. Chem.
  doi: 10.1039/b615954k
– volume: 56
  start-page: 10
  year: 1962
  ident: CH16144R12
  publication-title: Makromol. Chem.
  doi: 10.1002/macp.1962.020560102
– volume: 31
  start-page: 1319
  year: 1909
  ident: CH16144R4
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja01942a009
– volume: 31
  start-page: 1275
  year: 1993
  ident: CH16144R31
  publication-title: J. Polym. Sci. Part A: Polym. Chem.
  doi: 10.1002/pola.1993.080310523
– volume: 21
  start-page: 1941
  year: 2000
  ident: CH16144R48
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(00)00073-9
– volume: 171
  start-page: 33
  year: 2013
  ident: CH16144R72
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2013.06.024
– volume: 2
  start-page: 369
  year: 2013
  ident: CH16144R105
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201200181
– volume: 6
  start-page: 5464
  year: 2015
  ident: CH16144R124
  publication-title: Polym. Chem.
  doi: 10.1039/C5PY00843C
– volume: 69A
  start-page: 47
  year: 2004
  ident: CH16144R46
  publication-title: J. Biomed. Mater. Res. Part A
  doi: 10.1002/jbm.a.20101
– volume: 43
  start-page: 374
  year: 1998
  ident: CH16144R101
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/(SICI)1097-4636(199824)43:4<374::AID-JBM5>3.0.CO;2-5
– volume: 16
  start-page: 636
  year: 2015
  ident: CH16144R81
  publication-title: Biomacromolecules
  doi: 10.1021/bm5017282
– volume: 17
  start-page: 156
  year: 1999
  ident: CH16144R22
  publication-title: Nat. Biotechnol.
  doi: 10.1038/6152
– volume: 29
  start-page: 571
  year: 1991
  ident: CH16144R42
  publication-title: J. Polym. Sci. Part A: Polym. Chem.
  doi: 10.1002/pola.1991.080290413
– volume: 31
  start-page: 7124
  year: 2010
  ident: CH16144R128
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2010.06.011
– volume: 41
  start-page: 1059
  year: 2003
  ident: CH16144R45
  publication-title: J. Polym. Sci. Part A: Polym. Chem.
  doi: 10.1002/pola.10651
– volume: 28
  start-page: 387
  year: 1994
  ident: CH16144R57
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/jbm.820280314
– volume: 91B
  start-page: 938
  year: 2009
  ident: CH16144R121
  publication-title: J. Biomed. Mater. Res. Part B
  doi: 10.1002/jbm.b.31478
– volume: 22
  start-page: 23
  year: 1985
  ident: CH16144R20
  publication-title: J. Macromol. Sci., Chem.
  doi: 10.1080/00222338508063294
– volume: 13
  start-page: 314
  year: 2011
  ident: CH16144R36
  publication-title: Green Chem.
  doi: 10.1039/c0gc00773k
– volume: 19
  start-page: 1981
  year: 1998
  ident: CH16144R114
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(98)00109-4
– volume: 3
  start-page: 1171
  year: 2015
  ident: CH16144R47
  publication-title: Biomater. Sci.
  doi: 10.1039/C5BM00051C
– volume: 41
  start-page: 1511
  year: 2003
  ident: CH16144R50
  publication-title: J. Polym. Sci. Part A: Polym. Chem.
  doi: 10.1002/pola.10697
– volume: 29
  start-page: 2400
  year: 2008
  ident: CH16144R28
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2008.01.013
– volume: 125
  start-page: 98
  year: 2015
  ident: CH16144R93
  publication-title: Chem. Eng. Sci.
  doi: 10.1016/j.ces.2014.08.015
– volume: 20
  start-page: 51
  year: 1986
  ident: CH16144R96
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/jbm.820200106
– volume: 54
  start-page: 911
  year: 2002
  ident: CH16144R13
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(02)00051-0
– volume: 76A
  start-page: 102
  year: 2006
  ident: CH16144R103
  publication-title: J. Biomed. Mater. Res. Part A
  doi: 10.1002/jbm.a.30510
– volume: 9
  start-page: 8262
  year: 2013
  ident: CH16144R94
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2013.06.006
– volume: 29
  start-page: 343
  year: 1958
  ident: CH16144R8
  publication-title: J. Polym. Sci., Polym. Phys. Ed.
– volume: 57
  start-page: 281
  year: 2006
  ident: CH16144R71
  publication-title: Polym. Bull.
  doi: 10.1007/s00289-006-0561-z
– volume: 18
  start-page: 397
  year: 1997
  ident: CH16144R60
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(96)00151-2
– volume: 63
  start-page: 113
  year: 1967
  ident: CH16144R40
  publication-title: Chem. Weekbl.
– volume: 32
  start-page: 1343
  year: 2011
  ident: CH16144R37
  publication-title: Macromol. Rapid Commun.
  doi: 10.1002/marc.201100155
– volume: 21
  start-page: 1925
  year: 1988
  ident: CH16144R18
  publication-title: Macromolecules
  doi: 10.1021/ma00185a008
– volume: 45
  start-page: 3157
  year: 2004
  ident: CH16144R41
  publication-title: Polymer
  doi: 10.1016/j.polymer.2004.03.035
– volume: 28
  start-page: 1465
  year: 1994
  ident: CH16144R33
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/jbm.820281212
– volume: 33
  start-page: 94
  year: 2000
  ident: CH16144R56
  publication-title: Acc. Chem. Res.
  doi: 10.1021/ar9800993
– volume: 26
  start-page: 4105
  year: 1993
  ident: CH16144R52
  publication-title: Macromolecules
  doi: 10.1021/ma00068a006
– volume: 2
  start-page: 391
  year: 1968
  ident: CH16144R54
  publication-title: J. Macromol. Sci. Part B: Phys.
  doi: 10.1080/00222346808212871
– volume: 20
  start-page: 705
  year: 1987
  ident: CH16144R19
  publication-title: Macromolecules
  doi: 10.1021/ma00170a001
– volume: 51
  start-page: 352
  year: 2000
  ident: CH16144R107
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/1097-4636(20000905)51:3<352::AID-JBM8>3.0.CO;2-C
– start-page: 6415
  year: 2009
  ident: CH16144R29
  publication-title: Chem. Commun.
  doi: 10.1039/b911557a
– volume: 15
  start-page: 863
  year: 2014
  ident: CH16144R80
  publication-title: Biomacromolecules
  doi: 10.1021/bm401715z
– volume: 10
  start-page: 1527
  year: 1993
  ident: CH16144R85
  publication-title: Pharm. Res.
  doi: 10.1023/A:1018995913972
– volume: 26
  start-page: 537
  year: 1993
  ident: CH16144R55
  publication-title: Acc. Chem. Res.
  doi: 10.1021/ar00034a004
– volume: 48
  start-page: 322
  year: 1999
  ident: CH16144R98
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/(SICI)1097-4636(1999)48:3<322::AID-JBM17>3.0.CO;2-U
– volume: 17
  start-page: 103
  year: 1996
  ident: CH16144R58
  publication-title: Biomaterials
  doi: 10.1016/0142-9612(96)85755-3
– volume: 17
  start-page: 13215
  year: 2015
  ident: CH16144R65
  publication-title: Phys. Chem. Chem. Phys.
  doi: 10.1039/C5CP00473J
– volume: 103
  start-page: 541
  year: 2005
  ident: CH16144R66
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2004.12.021
– year: 2016
  ident: CH16144R108
  publication-title: J. Biomed. Mater. Res. Part A
– volume: 30
  start-page: 2598
  year: 1997
  ident: CH16144R59
  publication-title: Macromolecules
  doi: 10.1021/ma961627y
– volume: 14
  start-page: 854
  year: 2013
  ident: CH16144R76
  publication-title: Biomacromolecules
  doi: 10.1021/bm3018998
– volume: 24
  start-page: 3571
  year: 2003
  ident: CH16144R117
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(03)00219-9
– volume: 97
  start-page: 333
  year: 2004
  ident: CH16144R92
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2004.03.001
– volume: 34
  start-page: 4544
  year: 2013
  ident: CH16144R129
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.02.071
– volume: 25
  start-page: 12
  year: 1992
  ident: CH16144R38
  publication-title: Macromolecules
  doi: 10.1021/ma00027a003
– volume: 53
  start-page: 7891
  year: 2014
  ident: CH16144R35
  publication-title: Ind. Eng. Chem. Res.
  doi: 10.1021/ie500679u
– volume: 9
  start-page: 874
  year: 2012
  ident: CH16144R88
  publication-title: Mol. Pharm.
  doi: 10.1021/mp2004059
– volume: 41
  start-page: 3788
  year: 2003
  ident: CH16144R51
  publication-title: J. Polym. Sci. Part A: Polym. Chem.
  doi: 10.1002/pola.10951
– volume: 19
  start-page: 941
  year: 1985
  ident: CH16144R16
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/jbm.820190806
– volume: 29
  start-page: 1233
  year: 1995
  ident: CH16144R99
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/jbm.820291010
– volume: 5
  start-page: 203
  year: 2016
  ident: CH16144R26
  publication-title: ACS Macro Lett.
  doi: 10.1021/acsmacrolett.5b00854
– volume: 23
  start-page: 3212
  year: 1990
  ident: CH16144R39
  publication-title: Macromolecules
  doi: 10.1021/ma00215a003
– volume: 22
  start-page: 3388
  year: 2010
  ident: CH16144R132
  publication-title: Adv. Mater.
  doi: 10.1002/adma.200904447
– volume: 53
  start-page: 1
  year: 2013
  ident: CH16144R134
  publication-title: Polym. Rev.
  doi: 10.1080/15583724.2012.752745
– volume: 32
  start-page: 1
  year: 1959
  ident: CH16144R9
  publication-title: Makromol. Chem.
  doi: 10.1002/macp.1959.020320101
– volume: 54
  start-page: 933
  year: 2002
  ident: CH16144R95
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(02)00052-2
– volume: 112
  start-page: 4419
  year: 1990
  ident: CH16144R21
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja00167a045
– volume: 48
  start-page: 35
  year: 1997
  ident: CH16144R111
  publication-title: J. Control. Release
  doi: 10.1016/S0168-3659(97)00054-0
– volume: 72
  start-page: 846
  year: 2012
  ident: CH16144R130
  publication-title: React. Funct. Polym.
  doi: 10.1016/j.reactfunctpolym.2012.07.014
– volume: 90
  start-page: 552
  year: 1993
  ident: CH16144R53
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.90.2.552
– volume: 9
  start-page: 5583
  year: 2013
  ident: CH16144R90
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2012.11.001
– volume: 92
  start-page: 1677
  year: 2003
  ident: CH16144R118
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.10446
– volume: 63
  start-page: 170
  year: 2011
  ident: CH16144R125
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2010.10.008
– volume: 15
  start-page: 2573
  year: 2014
  ident: CH16144R109
  publication-title: Biomacromolecules
  doi: 10.1021/bm500420q
– volume: 102
  start-page: 2736
  year: 2014
  ident: CH16144R122
  publication-title: J. Biomed. Mater. Res. Part A
  doi: 10.1002/jbm.a.34949
– volume: 54
  start-page: 1569
  year: 1932
  ident: CH16144R6
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja01343a050
– volume: 102
  start-page: 4161
  year: 2014
  ident: CH16144R89
  publication-title: J. Biomed. Mater. Res. Part A
  doi: 10.1002/jbm.a.35086
– volume: 15
  start-page: 3406
  year: 2014
  ident: CH16144R70
  publication-title: Biomacromolecules
  doi: 10.1021/bm500927r
– volume: 30
  start-page: 1101
  year: 2009
  ident: CH16144R78
  publication-title: Macromol. Rapid Commun.
  doi: 10.1002/marc.200900059
– volume: 2
  start-page: 37
  year: 2001
  ident: CH16144R34
  publication-title: Biomacromolecules
  doi: 10.1021/bm000081r
– volume: 38
  start-page: 1989
  year: 2005
  ident: CH16144R64
  publication-title: Macromolecules
  doi: 10.1021/ma047661r
– volume: 16
  start-page: 1650
  year: 2015
  ident: CH16144R30
  publication-title: Biomacromolecules
  doi: 10.1021/acs.biomac.5b00280
– volume: 22
  start-page: 2117
  year: 1989
  ident: CH16144R24
  publication-title: Macromolecules
  doi: 10.1021/ma00195a018
– volume: 121
  start-page: 352
  year: 2011
  ident: CH16144R123
  publication-title: J. Appl. Polym. Sci.
  doi: 10.1002/app.33546
– volume: 24
  start-page: 1463
  year: 1990
  ident: CH16144R97
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/jbm.820241105
– volume: 7
  start-page: 2857
  year: 2011
  ident: CH16144R91
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2011.03.023
– volume: 28
  start-page: 5259
  year: 2007
  ident: CH16144R27
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2007.08.022
– volume: 60
  start-page: 129
  year: 1999
  ident: CH16144R84
  publication-title: J. Control. Release
  doi: 10.1016/S0168-3659(99)00071-1
– volume: 7
  start-page: 467
  year: 2012
  ident: CH16144R127
  publication-title: Nano Today
  doi: 10.1016/j.nantod.2012.08.005
– volume: 15
  start-page: 1889
  year: 2014
  ident: CH16144R75
  publication-title: Biomacromolecules
  doi: 10.1021/bm500303a
– volume: 34
  start-page: 1231
  year: 2013
  ident: CH16144R77
  publication-title: Macromol. Rapid Commun.
  doi: 10.1002/marc.201300323
– volume: 104
  start-page: 975
  year: 2016
  ident: CH16144R69
  publication-title: J. Biomed. Mater. Res. Part A
  doi: 10.1002/jbm.a.35630
– volume: 29
  start-page: 208
  year: 2014
  ident: CH16144R73
  publication-title: J. Bioact. Compat. Polym.
  doi: 10.1177/0883911514528410
– volume: 52
  start-page: 4110
  year: 1930
  ident: CH16144R5
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja01373a053
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Snippet This review focusses on polyanhydrides, a fascinating class of degradable polymers that have been used in and investigated for many bio-related applications...
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SubjectTerms Degradation
Erosion
Hydrolysis
Nanostructure
Polyanhydrides
Polymerization
Polymers
Synthesis
Title Polyanhydrides: Synthesis, Properties, and Applications
URI https://www.proquest.com/docview/1864554414
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