Tiotropium Respimat® improves physical functioning in chronic obstructive pulmonary disease
This observational study with tiotropium Respimat® was performed in a real-life setting to investigate its effectiveness with regard to physical functioning and tolerability. Patients with chronic obstructive pulmonary disease (COPD; n = 1,230; mean age, 65.5 years) received tiotropium 5 μg once dai...
Saved in:
Published in | International journal of chronic obstructive pulmonary disease Vol. 5; pp. 367 - 373 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New Zealand
Dove Medical Press
10.10.2010
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | This observational study with tiotropium Respimat® was performed in a real-life setting to investigate its effectiveness with regard to physical functioning and tolerability.
Patients with chronic obstructive pulmonary disease (COPD; n = 1,230; mean age, 65.5 years) received tiotropium 5 μg once daily via Respimat® Soft Inhaler for 6 weeks in an open-label observational study. At baseline and week 6, patients completed the Physical Function subdomain [PF-10] of the Short Form (SF) 36 questionnaire.
Improvement in standardized PF-10 score of ≥10 points was achieved by 61.5% of patients. Mean (SD) standardized PF-10 scores improved by 13.4 (15.9) points, from 49.0 (24.5) to 62.3 points (23.5; P < 0.001). Results in smokers (n = 435) were not significantly different to those in nonsmokers. The general condition of patients improved during treatment. Adverse events were reported by 4.0% of patients and were chiefly respiratory symptoms and dry mouth.
In COPD patients receiving tiotropium Respimat® in daily practice, physical function improved rapidly within 6 weeks of treatment, irrespective of smoking status. |
---|---|
AbstractList | This observational study with tiotropium Respimat® was performed in a real-life setting to investigate its effectiveness with regard to physical functioning and tolerability.
Patients with chronic obstructive pulmonary disease (COPD; n = 1,230; mean age, 65.5 years) received tiotropium 5 μg once daily via Respimat® Soft Inhaler for 6 weeks in an open-label observational study. At baseline and week 6, patients completed the Physical Function subdomain [PF-10] of the Short Form (SF) 36 questionnaire.
Improvement in standardized PF-10 score of ≥10 points was achieved by 61.5% of patients. Mean (SD) standardized PF-10 scores improved by 13.4 (15.9) points, from 49.0 (24.5) to 62.3 points (23.5; P < 0.001). Results in smokers (n = 435) were not significantly different to those in nonsmokers. The general condition of patients improved during treatment. Adverse events were reported by 4.0% of patients and were chiefly respiratory symptoms and dry mouth.
In COPD patients receiving tiotropium Respimat® in daily practice, physical function improved rapidly within 6 weeks of treatment, irrespective of smoking status. |
Author | Mitfessel, Harald Glaab, Thomas Rau-Berger, Heike |
AuthorAffiliation | 1 Medical Affairs Germany, Respiratory Medicine, Boehringer Ingelheim Pharma GmbH and Co. KG, Ingelheim 2 Pulmonology Practice, Remscheid, Germany |
AuthorAffiliation_xml | – name: 1 Medical Affairs Germany, Respiratory Medicine, Boehringer Ingelheim Pharma GmbH and Co. KG, Ingelheim – name: 2 Pulmonology Practice, Remscheid, Germany |
Author_xml | – sequence: 1 givenname: Heike surname: Rau-Berger fullname: Rau-Berger, Heike organization: Medical Affairs Germany, Respiratory Medicine, Boehringer Ingelheim Pharma GmbH and Co. KG, Ingelheim, Germany – sequence: 2 givenname: Harald surname: Mitfessel fullname: Mitfessel, Harald – sequence: 3 givenname: Thomas surname: Glaab fullname: Glaab, Thomas |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21103403$$D View this record in MEDLINE/PubMed |
BookMark | eNpVUNtKAzEQDVKxF33yXfIuW5Ps_UWQeoVCReubsGSzs21kNwnJbqE_5Uf4ZUarUp_mDOfMmZkzRgOlFSB0SsmU0Si9ENpUU0cjkrEDNKI0zQJGSDzYw0M0du7NgyRN6REaMkpJGJFwhF6XUndWG9m3-AmckS3vPt6xbI3VG3DYrLdOCt7guleik1pJtcJSYbG2HgusS9fZ3jMbwKZvWq243eJKOuAOjtFhzRsHJz91gl5ub5az-2C-uHuYXc0DweKsC-IyrRLI_W01zxmJCGMiLqM8iXybMA5JnUMKdUx5zDKaZDkwqCDjIAinkIYTdLnzNX3ZQiVAdZY3hbH-G7stNJfFf0bJdbHSm4LlGaUx9QbnOwNhtXMW6r9ZSoqvkIvZ4vG6eP4O2avP9tf9aX9TDT8B-5V-mw |
CitedBy_id | crossref_primary_10_1007_s40265_014_0307_4 crossref_primary_10_1038_s41533_021_00254_8 crossref_primary_10_1007_s12325_020_01557_x crossref_primary_10_1016_j_resp_2013_08_014 crossref_primary_10_1186_s12931_020_01407_y crossref_primary_10_1007_s40267_014_0181_x crossref_primary_10_1007_s41030_020_00122_9 crossref_primary_10_1007_s41030_021_00156_7 |
ContentType | Journal Article |
Copyright | 2010 Rau-Berger et al, publisher and licensee Dove Medical Press Ltd. |
Copyright_xml | – notice: 2010 Rau-Berger et al, publisher and licensee Dove Medical Press Ltd. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM |
DOI | 10.2147/copd.s14082 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1178-2005 |
EndPage | 373 |
ExternalDocumentID | 10_2147_COPD_S14082 21103403 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | Germany |
GeographicLocations_xml | – name: Germany |
GroupedDBID | --- 0YH 29J 2WC 53G 5GY 5VS ADBBV ADRAZ AENEX AFKRA ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV BENPR C1A CCPQU CGR CS3 CUY CVF DIK E3Z EBS ECM EIF EJD EMOBN F5P GROUPED_DOAJ GX1 HYE IAO IHR KQ8 M48 M~E NPM O5R O5S OK1 PGMZT PIMPY RNS RPM TR2 VDV AAYXX CITATION IHW INH INR ITC TDBHL 5PM |
ID | FETCH-LOGICAL-c258t-5b7d6e9677fa9204022c5b4964a9262ae6f9e7ef51a5281689e2ede8aec0a1e73 |
IEDL.DBID | RPM |
ISSN | 1178-2005 1176-9106 |
IngestDate | Tue Sep 17 21:08:01 EDT 2024 Fri Aug 23 02:55:55 EDT 2024 Fri Oct 18 09:12:16 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | physical function therapy COPD tiotropium |
Language | English |
License | This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c258t-5b7d6e9677fa9204022c5b4964a9262ae6f9e7ef51a5281689e2ede8aec0a1e73 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981151/ |
PMID | 21103403 |
PageCount | 7 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2981151 crossref_primary_10_2147_COPD_S14082 pubmed_primary_21103403 |
PublicationCentury | 2000 |
PublicationDate | 2010-Oct-10 |
PublicationDateYYYYMMDD | 2010-10-10 |
PublicationDate_xml | – month: 10 year: 2010 text: 2010-Oct-10 day: 10 |
PublicationDecade | 2010 |
PublicationPlace | New Zealand |
PublicationPlace_xml | – name: New Zealand |
PublicationTitle | International journal of chronic obstructive pulmonary disease |
PublicationTitleAlternate | Int J Chron Obstruct Pulmon Dis |
PublicationYear | 2010 |
Publisher | Dove Medical Press |
Publisher_xml | – name: Dove Medical Press |
SSID | ssj0056771 |
Score | 1.9936804 |
Snippet | This observational study with tiotropium Respimat® was performed in a real-life setting to investigate its effectiveness with regard to physical functioning... |
SourceID | pubmedcentral crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 367 |
SubjectTerms | Activities of Daily Living Administration, Inhalation Aged Bronchodilator Agents - administration & dosage Bronchodilator Agents - adverse effects Cholinergic Antagonists - administration & dosage Cholinergic Antagonists - adverse effects Female Germany Humans Male Middle Aged Nebulizers and Vaporizers Original Research Patient Satisfaction Prospective Studies Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - physiopathology Recovery of Function Scopolamine Derivatives - administration & dosage Scopolamine Derivatives - adverse effects Surveys and Questionnaires Time Factors Tiotropium Bromide Treatment Outcome |
SummonAdditionalLinks | – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LS8QwEA7rCuJFfLu-yGGvXds0adqDiKwui7Aqugt7EErTTrCwtnUf4v4pf4S_zKStxYoHobekDf1mwsxkJt8g1JYcQjM0bYOZwjGoHVlGQEAaQhLhSOFFIsqrLW6d_ojejNm4gb6bcZYAzv4M7XQ_qdF00nl_XV6oDX-uy5gtys-6d_dXnUdLt05eQauE2lSr-oBW6QTm8CLysniuFqy4qPf75ZppquxRvVbyh_HpbaKN0mvEl4WYt1ADkm20Nijz4jvoaRin82maxYsX_KCT58oP_fzAcX5iADOcldLA2oyVR7A4TnBYUOPiVJQ8sm-As8VEqWYwXeIyebOLRr3rYbdvlH0TjJAwd24wwSMHPPXTMvCI2qWEhExQz6GBZgcMwJEecJDMChjRfTc8IBCBGyixBRZwew81kzSBA4QtFjoqiAVXfY96JhMmSCpCLs2Q2eBCC7W_IfOzgh7DV2GFRtbXyPoFsi20X6BYTdJxp01Nu4V4Dd9qgqa9ro8k8XNOf008V7mx1uH_lj5C63nCP3-OUVOhCSfKj5iL01xHvgCWS8qc priority: 102 providerName: Scholars Portal |
Title | Tiotropium Respimat® improves physical functioning in chronic obstructive pulmonary disease |
URI | https://www.ncbi.nlm.nih.gov/pubmed/21103403 https://pubmed.ncbi.nlm.nih.gov/PMC2981151 |
Volume | 5 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEA66B_Eivl0fSw5ea5u0SdqjrK4irIoP2IOwNOkEC7ttWXcF_5Q_wl9mmqaLexVKLk1L-02SmclMvkHoXAtQgQpCjwWSe1GYES-loD2pqeRaJpnMbLbFPb99je5GbLSGWHsWxibtK5lfFJPpRZG_29zKaqr8Nk_Mfxz2aRIbQ4b462hdhGHrojfLL-Oi8bKI4GYmB7w5lFeX4_FVWZk1idQ1li0JMAnCqK2W5TTSUg2tpkj-0TmDbbTljEV82XzUDlqDYhdtDF04fA-9veTlfFZW-WKKn-qYuTE_f75xbjcK4ANXTgi41l5u5xXnBVYNIy4upaOP_QRcLSZmRKazL-xiNvvodXD90r_1XLkET1EWzz0mRcYhMf-v04SayUmpYjJKeJTWpIApcJ2AAM1IymhdbiMBChnEqZFWSkCEB6hTlAUcIUyY4sZ3hdi8L0oCJgPQkVRCB4qFEEMXnbeQjauGFWNsvIka5HH_4fFq_GxB7qLDBsVlpxbzLhIr-C471GzXq3fMILCs107ox_9-8gRt2tC_vU5RxwAMZ8aimMue9cRNezMiph1Gcc-OqV89ttKb |
link.rule.ids | 230,315,733,786,790,870,891,24346,27955,27956,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB0BlSgXKN8LbfGBa3YTJ3aSI1qKti1LUVkQB6QodsZqVDaJYBcJfhQ_gl-G4zirLrci5WY7Svxsz4z9_AbgUIUoXen6DnMFdwI_85yUonKEooIrEWciM2yLMz64DH5cs-sFYO1dGEPalyLvFrfjbpH_MdzKaix7LU-sdz7s0zjSjozXW4QPer5S1gbpzQLMeNjEWV7I9Vx2eXMtr07I05NlpVclr86ybGSAPdcP2nxZ1ibNDNE8SfIfq3OyBlft9zZkk7_d6UR05dMbKcf__qFPsGr9UHLUFK_DAhYbsDy0J-2bcDPKy8ldWeXTMfldH8drz_blmeRmDwLvSWXxJbVhtJu6JC-IbMR2SSmsMu0Dkmp6qwd7evdI7HHQFlyefBv1B47NxOBIyqKJw0SYcYx1x6o0pnreUyqZCGIepLXeYIpcxRiiYl7KaJ3JI0aKGUapHgiph6G_DUtFWeAuEI9JrsNijPT7gthlwkUVCBkqVzIfI-zAYYtFUjWCG4kOVGr0kv6v8-PkwqDXgZ0GnlmlFswOhHPAzSrUQtrzJRoOI6htu3_v3S0P4ONgNDxNTr-f_dyHFcMwMM9nWNKdjV-04zIRX80wfQXh6PHM |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbpwwEB21qRT1pZfcummb-iGvLGCwDY_Vpqs0bZJVLlIURULYjFXUXUDJbqXmo_IR_bIaY1bZPEbiDYPAx_bMeI7PAOxrgSpQQeSxQHIvjorQyylqT2oquZZpIQvLtjjhh5fx0RW7elTqy5L2lSyH1XQ2rMpfllvZzJTf88T8yfGIpolxZEK_KbT_El6ZOUtFH6h3izDjoou1QsHNfA54dzSvLcrjq7oxK1PYVlq2UsBhEMV9zSxnl5bGaJUo-cjyjN_Cdf_NHeHk93Axl0N1_0TO8Vk_9Q7eOH-UfO2avIcXWG3A-rHLuG_CzUVZz2_rplzMyFmbljce7r8HUtq9CLwjjcOZtAbSbe6SsiKqE90ltXQKtX-QNIupGfT57V_i0kJbcDn-djE69FxFBk9Rlsw9JkXBMTWdq_OUmvlPqWIyTnmct7qDOXKdokDNwpzRtqJHihQLTHIzIPIQRbQNa1Vd4QcgIVPchMeYmPfFacBkgDqWSuhAsQgTHMB-j0fWdMIbmQlYWgSz0enkIDu3CA5gp4No2agHdABiBbxlg1ZQe_WOgcQKazsIdp_95BdYnxyMs5_fT358hNeWaGCvT7Bm-ho_G_9lLvfsSP0PaET0TA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Tiotropium+Respimat%C2%AE+improves+physical+functioning+in+chronic+obstructive+pulmonary+disease&rft.jtitle=International+journal+of+chronic+obstructive+pulmonary+disease&rft.au=Rau-Berger%2C+Heike&rft.au=Mitfessel&rft.au=Glaab&rft.date=2010-10-10&rft.issn=1178-2005&rft.eissn=1178-2005&rft.spage=367&rft_id=info:doi/10.2147%2FCOPD.S14082&rft.externalDBID=n%2Fa&rft.externalDocID=10_2147_COPD_S14082 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1178-2005&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1178-2005&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1178-2005&client=summon |