Membrane/cytoskeleton communication

• Published in: Sub-cellular biochemistry Vol. 37; p. 247
• Main Author: Meiri, Karina F
• Format: Journal Article
• Language: English
• Published: United States 2004
• Subjects: Actins - physiology; Animals; Axons - physiology; Cell Membrane - physiology; Cytoskeleton - immunology; Cytoskeleton - physiology; Humans; Lymphocyte Activation; Membrane Microdomains - physiology; Phosphatidylinositol 4,5-Diphosphate - metabolism; rho GTP-Binding Proteins - metabolism; Signal Transduction - physiology; T-Lymphocytes - immunology

Accumulations of particular lipids in ordered arrays in the membrane (termed microdomains or lipid rafts) can attract proteins with specific targeting domains. Both the lipid and protein components of rafts communicate with the cytoskeleton directly thereby regulating cellular responses. Recent evid...