Structure Elucidation of Pharmaceutically Relevant Compounds Within Pyrene‐Based Frameworks

• Published in: Chemistry : a European journal Vol. 30; no. 68; pp. e202402958 - n/a
• Main Authors: Chaudhry, Mohammad T., Newman, Justin A., Lee, Alfred Y., Patel, Anisha
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 05.12.2024
• Subjects: Adenosine; Aromatic compounds; Benzaldehyde; Benzaldehydes - chemistry; Benzamide; Benzamides - chemistry; Chemical bonds; Complex formation; Crystallography; Crystallography, X-Ray; Crystals; Encapsulation; Functional groups; Guanidine - chemistry; Hydrogen Bonding; Hydrogen bonds; Lidocaine; Models, Molecular; Molecular Structure; Pharmaceutical Preparations - chemistry; Pharmaceuticals; Pyrene; Pyrenes - chemistry; Structure elucidation; Thymidine; Thymine; Uracil; Workflow; X-Ray Diffraction; Pyrene; Crystallography; Structure elucidation; Pharmaceuticals

Single‐crystal X‐ray diffraction (SCXRD) is the preferred and most accurate technique for determining molecular structures. However, it can present challenges when dealing with specific small molecules and active pharmaceutical ingredients (APIs), as many do not form quality crystals without coforme...