Hepatotoxic effects of aristolochic acid: mechanisms and implications

• Published in: Acta Materia Medica Vol. 3; no. 3; pp. 349 - 362
• Main Authors: Zhang, Qian, Chen, Jiayun, He, Hengkai, Zhao, Wentong, Wong, Yinkwan, Li, Wenhui, Feng, Sha, Liu, Bin, Wang, Jigang, Luo, Piao
• Format: Journal Article
• Language: English
• Published: Compuscript Ltd 30.09.2024

Herbal plants that contain aristolochic acids (AAs) have been widely used for medicinal purposes for centuries. However, human exposure to AAs via herbal or dietary intake is thought to be a causative factor for aristolochic acid nephropathy (AAN), hepatotoxic effects, and carcinomas. At present, th...