APMCG-1 attenuates ischemic stroke injury by reducing oxidative stress and apoptosis and promoting angiogenesis via activating PI3K/AKT pathway
Ischemic stroke (IS) is a major cause of mortality and morbidity worldwide. Beyond thrombolysis, strategies targeting anti-oxidative apoptosis and angiogenesis are considered prospective therapeutic strategies. Nevertheless, existing natural and clinical remedies have limited efficacy in the managem...
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| Published in | Biomedicine & pharmacotherapy Vol. 180; p. 117506 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Masson SAS
01.11.2024
Elsevier |
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| Abstract | Ischemic stroke (IS) is a major cause of mortality and morbidity worldwide. Beyond thrombolysis, strategies targeting anti-oxidative apoptosis and angiogenesis are considered prospective therapeutic strategies. Nevertheless, existing natural and clinical remedies have limited efficacy in the management of IS. Moreover, despite their millennial legacy of IS remediation, natural remedies such as ginseng incur high production costs. The novel glycopeptide APMCG-1, extracted from mountain-cultivated ginseng dregs in our previous study, is a potent therapeutic candidate for IS. This study investigated APMCG-1's remedial mechanisms against IS injury using an H2O2-induced oxidative stress paradigm in human umbilical vein endothelial cells (HUVECs) emulating ischemic endothelial cells, in a ponatinib-induced zebrafish IS model, and in rat middle cerebral artery occlusion (MCAO) prototypes. Cellular assays confirmed the proficiency of APMCG-1 in preventing oxidative stress and cell death, fostering regeneration, and facilitating neovascularization within the H2O2-stressed HUVECs framework. Moreover, APMCG-1 augmented hemodynamic velocity, oxidative stress mitigation, apoptosis reduction, and motor enhancement in a zebrafish model of IS. In MCAO rats, APMCG-1 ameliorated neurological deficits and cerebral injury, as evidenced by increased neurological scores and diminished infarct dimensions. In cells and animal models, APMCG-1 activated the PI3K/AKT signaling pathway, modulating factors such as Nrf2, Bcl-2, Caspase 3, eNOS, and VEGFA, thereby ameliorating cellular oxidative distress and catalyzing angiogenesis. Collectively, these results demonstrate the potential protective effects of APMCG-1 in IS pharmacotherapy and its prospective utility as an herbal-derived IS treatment modality.
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| AbstractList | Ischemic stroke (IS) is a major cause of mortality and morbidity worldwide. Beyond thrombolysis, strategies targeting anti-oxidative apoptosis and angiogenesis are considered prospective therapeutic strategies. Nevertheless, existing natural and clinical remedies have limited efficacy in the management of IS. Moreover, despite their millennial legacy of IS remediation, natural remedies such as ginseng incur high production costs. The novel glycopeptide APMCG-1, extracted from mountain-cultivated ginseng dregs in our previous study, is a potent therapeutic candidate for IS. This study investigated APMCG-1's remedial mechanisms against IS injury using an H2O2-induced oxidative stress paradigm in human umbilical vein endothelial cells (HUVECs) emulating ischemic endothelial cells, in a ponatinib-induced zebrafish IS model, and in rat middle cerebral artery occlusion (MCAO) prototypes. Cellular assays confirmed the proficiency of APMCG-1 in preventing oxidative stress and cell death, fostering regeneration, and facilitating neovascularization within the H2O2-stressed HUVECs framework. Moreover, APMCG-1 augmented hemodynamic velocity, oxidative stress mitigation, apoptosis reduction, and motor enhancement in a zebrafish model of IS. In MCAO rats, APMCG-1 ameliorated neurological deficits and cerebral injury, as evidenced by increased neurological scores and diminished infarct dimensions. In cells and animal models, APMCG-1 activated the PI3K/AKT signaling pathway, modulating factors such as Nrf2, Bcl-2, Caspase 3, eNOS, and VEGFA, thereby ameliorating cellular oxidative distress and catalyzing angiogenesis. Collectively, these results demonstrate the potential protective effects of APMCG-1 in IS pharmacotherapy and its prospective utility as an herbal-derived IS treatment modality.Ischemic stroke (IS) is a major cause of mortality and morbidity worldwide. Beyond thrombolysis, strategies targeting anti-oxidative apoptosis and angiogenesis are considered prospective therapeutic strategies. Nevertheless, existing natural and clinical remedies have limited efficacy in the management of IS. Moreover, despite their millennial legacy of IS remediation, natural remedies such as ginseng incur high production costs. The novel glycopeptide APMCG-1, extracted from mountain-cultivated ginseng dregs in our previous study, is a potent therapeutic candidate for IS. This study investigated APMCG-1's remedial mechanisms against IS injury using an H2O2-induced oxidative stress paradigm in human umbilical vein endothelial cells (HUVECs) emulating ischemic endothelial cells, in a ponatinib-induced zebrafish IS model, and in rat middle cerebral artery occlusion (MCAO) prototypes. Cellular assays confirmed the proficiency of APMCG-1 in preventing oxidative stress and cell death, fostering regeneration, and facilitating neovascularization within the H2O2-stressed HUVECs framework. Moreover, APMCG-1 augmented hemodynamic velocity, oxidative stress mitigation, apoptosis reduction, and motor enhancement in a zebrafish model of IS. In MCAO rats, APMCG-1 ameliorated neurological deficits and cerebral injury, as evidenced by increased neurological scores and diminished infarct dimensions. In cells and animal models, APMCG-1 activated the PI3K/AKT signaling pathway, modulating factors such as Nrf2, Bcl-2, Caspase 3, eNOS, and VEGFA, thereby ameliorating cellular oxidative distress and catalyzing angiogenesis. Collectively, these results demonstrate the potential protective effects of APMCG-1 in IS pharmacotherapy and its prospective utility as an herbal-derived IS treatment modality. Ischemic stroke (IS) is a major cause of mortality and morbidity worldwide. Beyond thrombolysis, strategies targeting anti-oxidative apoptosis and angiogenesis are considered prospective therapeutic strategies. Nevertheless, existing natural and clinical remedies have limited efficacy in the management of IS. Moreover, despite their millennial legacy of IS remediation, natural remedies such as ginseng incur high production costs. The novel glycopeptide APMCG-1, extracted from mountain-cultivated ginseng dregs in our previous study, is a potent therapeutic candidate for IS. This study investigated APMCG-1's remedial mechanisms against IS injury using an H2O2-induced oxidative stress paradigm in human umbilical vein endothelial cells (HUVECs) emulating ischemic endothelial cells, in a ponatinib-induced zebrafish IS model, and in rat middle cerebral artery occlusion (MCAO) prototypes. Cellular assays confirmed the proficiency of APMCG-1 in preventing oxidative stress and cell death, fostering regeneration, and facilitating neovascularization within the H2O2-stressed HUVECs framework. Moreover, APMCG-1 augmented hemodynamic velocity, oxidative stress mitigation, apoptosis reduction, and motor enhancement in a zebrafish model of IS. In MCAO rats, APMCG-1 ameliorated neurological deficits and cerebral injury, as evidenced by increased neurological scores and diminished infarct dimensions. In cells and animal models, APMCG-1 activated the PI3K/AKT signaling pathway, modulating factors such as Nrf2, Bcl-2, Caspase 3, eNOS, and VEGFA, thereby ameliorating cellular oxidative distress and catalyzing angiogenesis. Collectively, these results demonstrate the potential protective effects of APMCG-1 in IS pharmacotherapy and its prospective utility as an herbal-derived IS treatment modality. Ischemic stroke (IS) is a major cause of mortality and morbidity worldwide. Beyond thrombolysis, strategies targeting anti-oxidative apoptosis and angiogenesis are considered prospective therapeutic strategies. Nevertheless, existing natural and clinical remedies have limited efficacy in the management of IS. Moreover, despite their millennial legacy of IS remediation, natural remedies such as ginseng incur high production costs. The novel glycopeptide APMCG-1, extracted from mountain-cultivated ginseng dregs in our previous study, is a potent therapeutic candidate for IS. This study investigated APMCG-1's remedial mechanisms against IS injury using an H O -induced oxidative stress paradigm in human umbilical vein endothelial cells (HUVECs) emulating ischemic endothelial cells, in a ponatinib-induced zebrafish IS model, and in rat middle cerebral artery occlusion (MCAO) prototypes. Cellular assays confirmed the proficiency of APMCG-1 in preventing oxidative stress and cell death, fostering regeneration, and facilitating neovascularization within the H O -stressed HUVECs framework. Moreover, APMCG-1 augmented hemodynamic velocity, oxidative stress mitigation, apoptosis reduction, and motor enhancement in a zebrafish model of IS. In MCAO rats, APMCG-1 ameliorated neurological deficits and cerebral injury, as evidenced by increased neurological scores and diminished infarct dimensions. In cells and animal models, APMCG-1 activated the PI3K/AKT signaling pathway, modulating factors such as Nrf2, Bcl-2, Caspase 3, eNOS, and VEGFA, thereby ameliorating cellular oxidative distress and catalyzing angiogenesis. Collectively, these results demonstrate the potential protective effects of APMCG-1 in IS pharmacotherapy and its prospective utility as an herbal-derived IS treatment modality. Ischemic stroke (IS) is a major cause of mortality and morbidity worldwide. Beyond thrombolysis, strategies targeting anti-oxidative apoptosis and angiogenesis are considered prospective therapeutic strategies. Nevertheless, existing natural and clinical remedies have limited efficacy in the management of IS. Moreover, despite their millennial legacy of IS remediation, natural remedies such as ginseng incur high production costs. The novel glycopeptide APMCG-1, extracted from mountain-cultivated ginseng dregs in our previous study, is a potent therapeutic candidate for IS. This study investigated APMCG-1's remedial mechanisms against IS injury using an H2O2-induced oxidative stress paradigm in human umbilical vein endothelial cells (HUVECs) emulating ischemic endothelial cells, in a ponatinib-induced zebrafish IS model, and in rat middle cerebral artery occlusion (MCAO) prototypes. Cellular assays confirmed the proficiency of APMCG-1 in preventing oxidative stress and cell death, fostering regeneration, and facilitating neovascularization within the H2O2-stressed HUVECs framework. Moreover, APMCG-1 augmented hemodynamic velocity, oxidative stress mitigation, apoptosis reduction, and motor enhancement in a zebrafish model of IS. In MCAO rats, APMCG-1 ameliorated neurological deficits and cerebral injury, as evidenced by increased neurological scores and diminished infarct dimensions. In cells and animal models, APMCG-1 activated the PI3K/AKT signaling pathway, modulating factors such as Nrf2, Bcl-2, Caspase 3, eNOS, and VEGFA, thereby ameliorating cellular oxidative distress and catalyzing angiogenesis. Collectively, these results demonstrate the potential protective effects of APMCG-1 in IS pharmacotherapy and its prospective utility as an herbal-derived IS treatment modality. [Display omitted] |
| ArticleNumber | 117506 |
| Author | Dai, Yulin Liu, Meijun Meng, Ying Yang, Xiaoshan Wu, Mingdian Hu, Xuan He, Xingyue Chen, Likun Yue, Hao Zheng, Peng |
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| Cites_doi | 10.1007/s10571-020-00904-4 10.1007/s12975-021-00907-3 10.1016/j.jep.2023.116397 10.1001/jamanetworkopen.2023.17574 10.1016/j.jff.2023.105762 10.1038/s41401-018-0154-z 10.1016/j.redox.2023.102983 10.1161/JAHA.123.031669 10.1016/j.redox.2022.102363 10.1161/STROKEAHA.120.032935 10.1016/j.jgr.2017.11.001 10.1161/res.125.suppl_1.749 10.1186/s12866-021-02421-w 10.1016/j.phrs.2024.107175 10.1186/s12951-023-01862-x 10.1016/j.cub.2010.12.047 10.1007/s10811-020-02262-6 10.1016/S1474-4422(23)00277-6 10.1016/j.tips.2021.06.005 10.1093/eurheartj/ehac684 10.1038/s41522-022-00360-6 10.4103/bc.bc_52_22 10.3390/cells12091341 10.1155/2022/2122856 10.3390/jcm9051573 10.1155/2021/9919466 10.1177/17474930221080343 10.1016/j.biopha.2022.112719 10.1016/j.phymed.2023.154879 10.3390/antiox11122377 10.1073/pnas.2008762117 10.4103/bc.bc_50_23 10.1186/s13578-019-0297-8 10.1016/j.biopha.2023.115543 10.1161/01.STR.31.10.2295 10.1038/s41401-023-01061-2 10.1016/j.ejphar.2019.172418 10.1093/cvr/cvy298 10.4103/bc.bc_73_22 10.4103/1673-5374.382252 10.1016/j.biopha.2024.116625 10.1093/cvr/cvy157 |
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| Keywords | Mountain-cultivated ginseng Zebrafish Ischemic stroke MCAO models Glycopeptide PI3K/AKT |
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| References | Tao, Hu, Wu, Zhou, Yang, Li, Fu, Zheng, Yue, Dai (bib24) 2023; 116 Wu, Song, Zhang, Wang, Zhang, Xiong, Zhuang, Zang, Li, Fang, Qu, Wang, Zhang, Li, Wang, Li, Xia, Yao, Nie, Gao, Ji (bib29) 2023; 6 Ni, Wang, Cai, Yang, Alolga, Liu, Li, Huang (bib33) 2022 Fang, Wang, Miao (bib40) 2023; 44 Cui, Wang, Zhang, Wei, Wang (bib48) 2022; 2022 Zhuang, Xu, Hu, Wu, Li, Lee, Yu, Dai, Jeon (bib21) 2024; 265 Lin, Xie, Zhong, Huang, Shi, Yao (bib34) 2021 Wang, Niu, Li, Han, Liu, Chu, Sha, Zhao (bib36) 2023; 21 Hsieh, Chi, Chiou (bib12) 2019 Li, Xue, Li, Cui, Gao, Li, Chen, Zhang, Xu, Jiang, Zhang, Wang (bib31) 2024; 174 Widimsky, Snyder, Sulzenko, Hopkins, Stetkarova (bib6) 2023; 44 Zhang, Feng, Si, Lu, Wang, Wang, Li, Xie, Yue, Yong, Dai, Zhang, Li (bib46) 2024; 69 Eren, Yilmaz (bib15) 2022; 8 Corrigendum to: World Stroke Organization (WSO) (bib4) 2022; 17 Guo, Pang, Gao, Meng, Jin (bib26) 2023; 167 Liao, Gong, Zhou, Xue, Li, Peng (bib19) 2021; 2021 Qin, Yang, Chu, Zhang, Pang, Chen, Zhou, Chen, Tian, Wang (bib42) 2022 Lorente, Martín, González-Rivero, Pérez-Cejas, Ramos-Gómez, Solé-Violán, Cáceres, Villacampa-Jiménez, Jiménez (bib49) 2021; 30 Chu, Zhang, Zhou, He, Chen, Luo, Liu, Ai, Gong, Wang, Sun, Feng, Chen (bib32) 2019; 40 Feigin, Owolabi (bib5) 2023; 22 Lin, Feng, Xu (bib25) 2019; 9 Li, Zhou, Wu, Lee, Zheng, Dai, Yue (bib18) 2024; 336 Chen, Zhang, Liu, Zhang, Shang, Xue, Chen, Xing, Song, Xu (bib43) 2019; 856 Venema, Roozenbeek, Mulder, Brown, Majoie, Steyerberg, Demchuk, Muir, Dávalos, Mitchell, Bracard, Berkhemer, Lycklama À Nijeholt, Van Oostenbrugge, Roos, Van Zwam, Van Der Lugt, Hill, White, Campbell, Guillemin, Saver, Jovin, Goyal, Dippel, Lingsma, Null (bib9) 2021 Zhu, Wang, Wang, Wan (bib41) 2022; 148 Chen, Xie, Yu, Li, Chen, Xie, Huang, Zhang, Zhang, Li (bib20) 2021; 12 Chen (bib47) 2021; 42 Wang, Zhang, Xiong, Zhu, Chen, Zhang, Chen, Jian (bib38) 2022; 11 Zhao, Liu, Yao, Zhang, Yao, Feng, Liu, Zhou (bib17) 2022; 13 Uzuner, Uzuner (bib3) 2023; 9 Lin, Liu, Sun, Liang, Li, Ye, Ma, Fan, Shen, Jin, He (bib22) 2023; 314 Gu, Yin, Lu, Lu, Jiang, Yin (bib8) 2024; 10 Liu, Paterson, Baumgardt, Irwin, Xia, Bosnjak, Ge (bib52) 2019; 115 Ma, Li, Zhang, Jiang, Gao, Mangal, Ding, Yin, Ji (bib10) 2021; 7 Dai, Jiang, Nie, Lu, Kang, Jeon (bib23) 2020; 32 Yuan, Wulf, Burga, Cantley (bib45) 2011 Minjares, Wu, Wang (bib11) 2023; 12 Fang, Wang, Zhao, Wang, Sun (bib35) 2022; 22 Ghannam, Almajali, Galecio-Castillo, Al Qudah, Khasiyev, Dibas, Ghazaleh, Vivanco-Suarez, Moran-Marinos, Farooqui, Rodriguez-Calienes, Koul, Roeder, Shim, Samaniego, Leira, Adams, Ortega-Gutierrez (bib7) 2023; 12 Guo, Pang, Gao, Meng, Jin (bib13) 2023; 167 Song, Gao, Shi, Li, Zheng (bib30) 2023; 109 Li, Li, Li, Men, Zuo, Gong (bib28) 2024; 203 Owolabi, Thrift, Mahal (bib2) 2022; 7 Cherubini, Polidori, Bregnocchi, Pezzuto, Cecchetti, Ingegni, Di Iorio, Senin, Mecocci (bib37) 2000 Sui, Sun, Zhang, Li, Han, Zheng, Xin (bib14) 2021; 41 Simchi, Panov, Morsy, Feuermann, Kaphzan (bib50) 2020; 9 Xu, Chen, Zhang, Shaukat, Lin, Yue, Ding, Tong, Liu, He, Xie, Liu, Zhang, Zhang, Huang (bib51) 2023; 9 Zhou, Sun, Xu, Chen, Huang, Hamblin, Foley, Hitchens, Li, Yin (bib1) 2022; 9 Dai, Qiao, Yu, Zheng, Yue, Liu (bib16) 2020; 44 Guo, Shao, Wang, Zhao, Wang (bib27) 2020 Lau, Cao, Fu, Ip (bib39) 2020; 117 Chen, Zhabyeyev, Azad, Wang, Minerath, Desaulniers, Grueter, Murray, Kassiri, Vanhaesebroeck, Oudit (bib53) 2019; 115 Wu, Sun, Lin, Wang, Hai (bib44) 2024; 19 Wang (10.1016/j.biopha.2024.117506_bib36) 2023; 21 Ni (10.1016/j.biopha.2024.117506_bib33) 2022 Hsieh (10.1016/j.biopha.2024.117506_bib12) 2019 Owolabi (10.1016/j.biopha.2024.117506_bib2) 2022; 7 Zhuang (10.1016/j.biopha.2024.117506_bib21) 2024; 265 Lorente (10.1016/j.biopha.2024.117506_bib49) 2021; 30 Fang (10.1016/j.biopha.2024.117506_bib40) 2023; 44 Li (10.1016/j.biopha.2024.117506_bib28) 2024; 203 Chen (10.1016/j.biopha.2024.117506_bib20) 2021; 12 Tao (10.1016/j.biopha.2024.117506_bib24) 2023; 116 Sui (10.1016/j.biopha.2024.117506_bib14) 2021; 41 Lin (10.1016/j.biopha.2024.117506_bib25) 2019; 9 Song (10.1016/j.biopha.2024.117506_bib30) 2023; 109 Lin (10.1016/j.biopha.2024.117506_bib34) 2021 Zhu (10.1016/j.biopha.2024.117506_bib41) 2022; 148 Lin (10.1016/j.biopha.2024.117506_bib22) 2023; 314 Cherubini (10.1016/j.biopha.2024.117506_bib37) 2000 Dai (10.1016/j.biopha.2024.117506_bib23) 2020; 32 Fang (10.1016/j.biopha.2024.117506_bib35) 2022; 22 Chu (10.1016/j.biopha.2024.117506_bib32) 2019; 40 Simchi (10.1016/j.biopha.2024.117506_bib50) 2020; 9 Dai (10.1016/j.biopha.2024.117506_bib16) 2020; 44 Guo (10.1016/j.biopha.2024.117506_bib26) 2023; 167 Chen (10.1016/j.biopha.2024.117506_bib53) 2019; 115 Uzuner (10.1016/j.biopha.2024.117506_bib3) 2023; 9 Corrigendum to: World Stroke Organization (WSO) (10.1016/j.biopha.2024.117506_bib4) 2022; 17 Ma (10.1016/j.biopha.2024.117506_bib10) 2021; 7 Zhao (10.1016/j.biopha.2024.117506_bib17) 2022; 13 Cui (10.1016/j.biopha.2024.117506_bib48) 2022; 2022 Chen (10.1016/j.biopha.2024.117506_bib43) 2019; 856 Wu (10.1016/j.biopha.2024.117506_bib44) 2024; 19 Liu (10.1016/j.biopha.2024.117506_bib52) 2019; 115 Ghannam (10.1016/j.biopha.2024.117506_bib7) 2023; 12 Li (10.1016/j.biopha.2024.117506_bib31) 2024; 174 Minjares (10.1016/j.biopha.2024.117506_bib11) 2023; 12 Yuan (10.1016/j.biopha.2024.117506_bib45) 2011 Chen (10.1016/j.biopha.2024.117506_bib47) 2021; 42 Guo (10.1016/j.biopha.2024.117506_bib13) 2023; 167 Wu (10.1016/j.biopha.2024.117506_bib29) 2023; 6 Zhou (10.1016/j.biopha.2024.117506_bib1) 2022; 9 Zhang (10.1016/j.biopha.2024.117506_bib46) 2024; 69 Xu (10.1016/j.biopha.2024.117506_bib51) 2023; 9 Wang (10.1016/j.biopha.2024.117506_bib38) 2022; 11 Venema (10.1016/j.biopha.2024.117506_bib9) 2021 Widimsky (10.1016/j.biopha.2024.117506_bib6) 2023; 44 Eren (10.1016/j.biopha.2024.117506_bib15) 2022; 8 Lau (10.1016/j.biopha.2024.117506_bib39) 2020; 117 Feigin (10.1016/j.biopha.2024.117506_bib5) 2023; 22 Guo (10.1016/j.biopha.2024.117506_bib27) 2020 Gu (10.1016/j.biopha.2024.117506_bib8) 2024; 10 Li (10.1016/j.biopha.2024.117506_bib18) 2024; 336 Liao (10.1016/j.biopha.2024.117506_bib19) 2021; 2021 Qin (10.1016/j.biopha.2024.117506_bib42) 2022 |
| References_xml | – volume: 9 start-page: 21 year: 2023 end-page: 24 ident: bib3 article-title: Risk factors for multiple recurrent ischemic strokes publication-title: Brain Circ. contributor: fullname: Uzuner – volume: 44 start-page: 205 year: 2020 end-page: 214 ident: bib16 article-title: Comparing eight types of ginsenosides in ginseng of different plant ages and regions using RRLC-Q-TOF MS/MS publication-title: J. Ginseng Res. contributor: fullname: Liu – volume: 116 year: 2023 ident: bib24 article-title: Characterization and screening of anti-melanogenesis and anti-photoaging activity of different enzyme-assisted polysaccharide extracts from Portulaca oleracea L. publication-title: Phytomedicine contributor: fullname: Dai – volume: 9 start-page: 38 year: 2019 ident: bib25 article-title: Cardioprotective effects of microRNA-18a on acute myocardial infarction by promoting cardiomyocyte autophagy and suppressing cellular senescence via brain derived neurotrophic factor publication-title: Cell Biosci. contributor: fullname: Xu – volume: 115 start-page: 1343 year: 2019 end-page: 1356 ident: bib53 article-title: Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury publication-title: Cardiovasc. Res. contributor: fullname: Oudit – volume: 8 start-page: 172 year: 2022 end-page: 179 ident: bib15 article-title: Neuroprotective approach in acute ischemic stroke: a systematic review of clinical and experimental studies publication-title: Brain Circ. contributor: fullname: Yilmaz – year: 2019 ident: bib12 article-title: Abstract 749: circulating miRNAs and apoptosis genes with hyperglycemia in ischemic stroke patient publication-title: Circ. Res. contributor: fullname: Chiou – year: 2000 ident: bib37 article-title: Antioxidant profile and early outcome in stroke patients publication-title: Stroke contributor: fullname: Mecocci – volume: 314 year: 2023 ident: bib22 article-title: Qilong capsule alleviates ponatinib-induced ischemic stroke in a zebrafish model by regulating coagulation, inflammation and apoptosis publication-title: J. Ethnopharmacol. contributor: fullname: He – volume: 856 year: 2019 ident: bib43 article-title: Ginsenoside Rg1 promotes cerebral angiogenesis via the PI3K/Akt/mTOR signaling pathway in ischemic mice publication-title: Eur. J. Pharmacol. contributor: fullname: Xu – volume: 7 start-page: 241 year: 2021 end-page: 246 ident: bib10 article-title: Protection of multiple ischemic organs by controlled reperfusion publication-title: Brain B contributor: fullname: Ji – volume: 12 start-page: 695 year: 2021 end-page: 710 ident: bib20 article-title: Zebrafish as a model for in-depth mechanistic study for stroke publication-title: Transl. Stroke Res. contributor: fullname: Li – volume: 13 year: 2022 ident: bib17 article-title: A review of neuroprotective effects and mechanisms of ginsenosides from panax ginseng in treating ischemic stroke publication-title: Front. Pharm. contributor: fullname: Zhou – volume: 6 year: 2023 ident: bib29 article-title: Efficacy and safety of panax notoginseng saponins in the treatment of adults with ischemic stroke in china: a randomized clinical trial publication-title: JAMA Netw. Open contributor: fullname: Ji – volume: 117 start-page: 25800 year: 2020 end-page: 25809 ident: bib39 article-title: Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Ip – volume: 265 year: 2024 ident: bib21 article-title: In vitro and in vivo anti-inflammatory properties of an active fucoidan fraction from Sargassum fusiforme and a fraction-based hydrogel publication-title: Int. J. Biol. Macromol. contributor: fullname: Jeon – year: 2020 ident: bib27 article-title: Recent progress in polysaccharides from Panax ginseng C. A. Meyer publication-title: Food Funct. contributor: fullname: Wang – volume: 174 year: 2024 ident: bib31 article-title: Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway publication-title: Biomed. Pharmacother. contributor: fullname: Wang – volume: 19 start-page: 887 year: 2024 end-page: 894 ident: bib44 article-title: Sustained release of vascular endothelial growth factor A and basic fibroblast growth factor from nanofiber membranes reduces oxygen/glucose deprivation-induced injury to neurovascular units publication-title: Neural Regen. Res. contributor: fullname: Hai – volume: 40 start-page: 13 year: 2019 end-page: 25 ident: bib32 article-title: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway publication-title: Acta Pharmacol. Sin. contributor: fullname: Chen – volume: 9 start-page: 1 year: 2023 ident: bib51 article-title: Gut microbiome dysregulation drives bone damage in broiler tibial dyschondroplasia by disrupting glucose homeostasis publication-title: NPJ Biofilms Micro contributor: fullname: Huang – volume: 115 start-page: 168 year: 2019 end-page: 178 ident: bib52 article-title: Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning publication-title: Cardiovasc. Res. contributor: fullname: Ge – volume: 32 start-page: 4289 year: 2020 end-page: 4298 ident: bib23 article-title: Hepato-protective effect of fucoidan extracted from acid-processed Sargassum fusiformisin ethanol-treated Chang liver cells and in a zebrafish model publication-title: J. Appl. Phycol. contributor: fullname: Jeon – volume: 30 year: 2021 ident: bib49 article-title: Serum levels of B-cell lymphoma-2 anti-apoptotic protein and malignant middle cerebral artery infarction mortality publication-title: J. Stroke Cereb. Dis. contributor: fullname: Jiménez – volume: 148 year: 2022 ident: bib41 article-title: Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: applications for natural compounds from medicinal herbs publication-title: Biomed. Pharm. contributor: fullname: Wan – volume: 22 start-page: 1160 year: 2023 end-page: 1206 ident: bib5 article-title: N. World Stroke Org Lancet, Pragmatic solutions to reduce the global burden of stroke a World Stroke Organization-Lancet Neurology Commission publication-title: Lancet Neurol. contributor: fullname: Owolabi – volume: 9 year: 2020 ident: bib50 article-title: Novel insights into the role of UBE3A in regulating apoptosis and proliferation publication-title: J. Clin. Med. contributor: fullname: Kaphzan – volume: 12 year: 2023 ident: bib11 article-title: Oxidative stress and MicroRNAs in endothelial cells under metabolic disorders publication-title: Cells contributor: fullname: Wang – volume: 109 year: 2023 ident: bib30 article-title: Panax ginseng and its derivatives: promoting angiogenesis in ischemic diseases - a mechanistic overview publication-title: J. Funct. Foods contributor: fullname: Zheng – volume: 167 year: 2023 ident: bib13 article-title: Lyoniresinol attenuates cerebral ischemic stroke injury in MCAO rat based on oxidative stress suppression via regulation of Akt/GSK-3β/Nrf2 signaling publication-title: Biomed. Pharmacother. contributor: fullname: Jin – year: 2021 ident: bib34 article-title: Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer publication-title: J. Ginseng Res. contributor: fullname: Yao – volume: 41 start-page: 1311 year: 2021 end-page: 1324 ident: bib14 article-title: LncRNA MEG8 attenuates cerebral ischemia after ischemic stroke through targeting miR-130a-5p/VEGFA signaling publication-title: Cell Mol. Neurobiol. contributor: fullname: Xin – year: 2022 ident: bib42 article-title: Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions publication-title: Signal Transduct. Target. Ther. contributor: fullname: Wang – volume: 42 start-page: 729 year: 2021 end-page: 744 ident: bib47 article-title: Nrf2 for cardiac protection: pharmacological options against oxidative stress publication-title: Trends Pharm. Sci. contributor: fullname: Chen – year: 2011 ident: bib45 article-title: Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations publication-title: Curr. Biol. contributor: fullname: Cantley – volume: 12 year: 2023 ident: bib7 article-title: Intravenous thrombolysis for acute ischemic stroke in patients with recent direct oral anticoagulant use: a systematic review and meta-analysis publication-title: J. Am. Heart Assoc. contributor: fullname: Ortega-Gutierrez – volume: 9 year: 2022 ident: bib1 article-title: Genetic deficiency of MicroRNA-15a/16-1 confers resistance to neuropathological damage and cognitive dysfunction in experimental vascular cognitive impairment and dementia publication-title: Adv. Sci. (Weinh.) contributor: fullname: Yin – year: 2021 ident: bib9 article-title: Prediction of outcome and endovascular treatment benefit: validation and update of the MR PREDICTS decision tool publication-title: Stroke contributor: fullname: Null – volume: 2022 year: 2022 ident: bib48 article-title: Plin5, a new target in diabetic cardiomyopathy publication-title: Oxid. Med. Cell Longev. contributor: fullname: Wang – volume: 44 start-page: 1205 year: 2023 end-page: 1215 ident: bib6 article-title: Acute ischaemic stroke: recent advances in reperfusion treatment publication-title: Eur. Heart J. contributor: fullname: Stetkarova – volume: 167 year: 2023 ident: bib26 article-title: Lyoniresinol attenuates cerebral ischemic stroke injury in MCAO rat based on oxidative stress suppression via regulation of Akt/GSK-3β/Nrf2 signaling publication-title: Biomed. Pharm. contributor: fullname: Jin – year: 2022 ident: bib33 article-title: Ginsenoside Rb1 inhibits astrocyte activation and promotes transfer of astrocytic mitochondria to neurons against ischemic stroke publication-title: Redox Biol. contributor: fullname: Huang – volume: 17 start-page: 478 year: 2022 ident: bib4 article-title: Global Stroke Fact Sheet 2022 publication-title: Int. J. Stroke: Off. J. Int. Stroke Soc. contributor: fullname: Corrigendum to: World Stroke Organization (WSO) – volume: 44 start-page: 1305 year: 2023 end-page: 1321 ident: bib40 article-title: Angiogenesis after ischemic stroke publication-title: Acta Pharm. Sin. contributor: fullname: Miao – volume: 2021 year: 2021 ident: bib19 article-title: Leonurine ameliorates oxidative stress and insufficient angiogenesis by regulating the PI3K/Akt-eNOS signaling pathway in H(2)O(2)-induced HUVECs publication-title: Oxid. Med Cell Longev. contributor: fullname: Peng – volume: 336 year: 2024 ident: bib18 article-title: A novel glycopeptide from mountain-cultivated ginseng residue protects type 2 diabetic symptoms-induced heart failure publication-title: J. Ethnopharmacol. contributor: fullname: Yue – volume: 21 start-page: 109 year: 2023 ident: bib36 article-title: Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis publication-title: J. Nanobiotechnol. contributor: fullname: Zhao – volume: 69 year: 2024 ident: bib46 article-title: Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation publication-title: Redox Biol. contributor: fullname: Li – volume: 7 year: 2022 ident: bib2 article-title: Primary stroke prevention worldwide: translating evidence into action (vol 7, pg e74, 2022 publication-title: Lancet Public Health contributor: fullname: Mahal – volume: 203 year: 2024 ident: bib28 article-title: Cisplatin-based combination therapies: their efficacy with a focus on ginsenosides co-administration publication-title: Pharmacol. Res. contributor: fullname: Gong – volume: 11 year: 2022 ident: bib38 article-title: Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke publication-title: Antioxidants contributor: fullname: Jian – volume: 22 start-page: 2 year: 2022 ident: bib35 article-title: Diversity and structure of the rhizosphere microbial communities of wild and cultivated ginseng publication-title: BMC Microbiol. contributor: fullname: Sun – volume: 10 start-page: 42 year: 2024 end-page: 50 ident: bib8 article-title: Risk factors for intraprocedural hypoxemia in patients with acute cerebral ischemia treated with vascular intervention and its impact on prognosis: a retrospective cohort study publication-title: Brain Circ. contributor: fullname: Yin – volume: 41 start-page: 1311 issue: 6 year: 2021 ident: 10.1016/j.biopha.2024.117506_bib14 article-title: LncRNA MEG8 attenuates cerebral ischemia after ischemic stroke through targeting miR-130a-5p/VEGFA signaling publication-title: Cell Mol. Neurobiol. doi: 10.1007/s10571-020-00904-4 contributor: fullname: Sui – volume: 12 start-page: 695 issue: 5 year: 2021 ident: 10.1016/j.biopha.2024.117506_bib20 article-title: Zebrafish as a model for in-depth mechanistic study for stroke publication-title: Transl. Stroke Res. doi: 10.1007/s12975-021-00907-3 contributor: fullname: Chen – volume: 314 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib22 article-title: Qilong capsule alleviates ponatinib-induced ischemic stroke in a zebrafish model by regulating coagulation, inflammation and apoptosis publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2023.116397 contributor: fullname: Lin – volume: 6 issue: 6 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib29 article-title: Efficacy and safety of panax notoginseng saponins in the treatment of adults with ischemic stroke in china: a randomized clinical trial publication-title: JAMA Netw. Open doi: 10.1001/jamanetworkopen.2023.17574 contributor: fullname: Wu – volume: 109 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib30 article-title: Panax ginseng and its derivatives: promoting angiogenesis in ischemic diseases - a mechanistic overview publication-title: J. Funct. Foods doi: 10.1016/j.jff.2023.105762 contributor: fullname: Song – volume: 40 start-page: 13 issue: 1 year: 2019 ident: 10.1016/j.biopha.2024.117506_bib32 article-title: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway publication-title: Acta Pharmacol. Sin. doi: 10.1038/s41401-018-0154-z contributor: fullname: Chu – volume: 69 year: 2024 ident: 10.1016/j.biopha.2024.117506_bib46 article-title: Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation publication-title: Redox Biol. doi: 10.1016/j.redox.2023.102983 contributor: fullname: Zhang – volume: 12 issue: 24 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib7 article-title: Intravenous thrombolysis for acute ischemic stroke in patients with recent direct oral anticoagulant use: a systematic review and meta-analysis publication-title: J. Am. Heart Assoc. doi: 10.1161/JAHA.123.031669 contributor: fullname: Ghannam – volume: 336 year: 2024 ident: 10.1016/j.biopha.2024.117506_bib18 article-title: A novel glycopeptide from mountain-cultivated ginseng residue protects type 2 diabetic symptoms-induced heart failure publication-title: J. Ethnopharmacol. contributor: fullname: Li – year: 2022 ident: 10.1016/j.biopha.2024.117506_bib33 article-title: Ginsenoside Rb1 inhibits astrocyte activation and promotes transfer of astrocytic mitochondria to neurons against ischemic stroke publication-title: Redox Biol. doi: 10.1016/j.redox.2022.102363 contributor: fullname: Ni – year: 2021 ident: 10.1016/j.biopha.2024.117506_bib9 article-title: Prediction of outcome and endovascular treatment benefit: validation and update of the MR PREDICTS decision tool publication-title: Stroke doi: 10.1161/STROKEAHA.120.032935 contributor: fullname: Venema – volume: 44 start-page: 205 issue: 2 year: 2020 ident: 10.1016/j.biopha.2024.117506_bib16 article-title: Comparing eight types of ginsenosides in ginseng of different plant ages and regions using RRLC-Q-TOF MS/MS publication-title: J. Ginseng Res. doi: 10.1016/j.jgr.2017.11.001 contributor: fullname: Dai – year: 2019 ident: 10.1016/j.biopha.2024.117506_bib12 article-title: Abstract 749: circulating miRNAs and apoptosis genes with hyperglycemia in ischemic stroke patient publication-title: Circ. Res. doi: 10.1161/res.125.suppl_1.749 contributor: fullname: Hsieh – volume: 22 start-page: 2 issue: 1 year: 2022 ident: 10.1016/j.biopha.2024.117506_bib35 article-title: Diversity and structure of the rhizosphere microbial communities of wild and cultivated ginseng publication-title: BMC Microbiol. doi: 10.1186/s12866-021-02421-w contributor: fullname: Fang – volume: 203 year: 2024 ident: 10.1016/j.biopha.2024.117506_bib28 article-title: Cisplatin-based combination therapies: their efficacy with a focus on ginsenosides co-administration publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2024.107175 contributor: fullname: Li – volume: 21 start-page: 109 issue: 1 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib36 article-title: Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis publication-title: J. Nanobiotechnol. doi: 10.1186/s12951-023-01862-x contributor: fullname: Wang – year: 2011 ident: 10.1016/j.biopha.2024.117506_bib45 article-title: Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations publication-title: Curr. Biol. doi: 10.1016/j.cub.2010.12.047 contributor: fullname: Yuan – volume: 32 start-page: 4289 issue: 6 year: 2020 ident: 10.1016/j.biopha.2024.117506_bib23 article-title: Hepato-protective effect of fucoidan extracted from acid-processed Sargassum fusiformisin ethanol-treated Chang liver cells and in a zebrafish model publication-title: J. Appl. Phycol. doi: 10.1007/s10811-020-02262-6 contributor: fullname: Dai – volume: 22 start-page: 1160 issue: 12 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib5 article-title: N. World Stroke Org Lancet, Pragmatic solutions to reduce the global burden of stroke a World Stroke Organization-Lancet Neurology Commission publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(23)00277-6 contributor: fullname: Feigin – volume: 7 start-page: 241 issue: 4 year: 2021 ident: 10.1016/j.biopha.2024.117506_bib10 article-title: Protection of multiple ischemic organs by controlled reperfusion publication-title: Brain B contributor: fullname: Ma – volume: 42 start-page: 729 issue: 9 year: 2021 ident: 10.1016/j.biopha.2024.117506_bib47 article-title: Nrf2 for cardiac protection: pharmacological options against oxidative stress publication-title: Trends Pharm. Sci. doi: 10.1016/j.tips.2021.06.005 contributor: fullname: Chen – volume: 265 issue: Pt 1 year: 2024 ident: 10.1016/j.biopha.2024.117506_bib21 article-title: In vitro and in vivo anti-inflammatory properties of an active fucoidan fraction from Sargassum fusiforme and a fraction-based hydrogel publication-title: Int. J. Biol. Macromol. contributor: fullname: Zhuang – volume: 44 start-page: 1205 issue: 14 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib6 article-title: Acute ischaemic stroke: recent advances in reperfusion treatment publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehac684 contributor: fullname: Widimsky – volume: 9 start-page: 1 issue: 1 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib51 article-title: Gut microbiome dysregulation drives bone damage in broiler tibial dyschondroplasia by disrupting glucose homeostasis publication-title: NPJ Biofilms Micro doi: 10.1038/s41522-022-00360-6 contributor: fullname: Xu – volume: 9 issue: 17 year: 2022 ident: 10.1016/j.biopha.2024.117506_bib1 article-title: Genetic deficiency of MicroRNA-15a/16-1 confers resistance to neuropathological damage and cognitive dysfunction in experimental vascular cognitive impairment and dementia publication-title: Adv. Sci. (Weinh.) contributor: fullname: Zhou – volume: 8 start-page: 172 issue: 4 year: 2022 ident: 10.1016/j.biopha.2024.117506_bib15 article-title: Neuroprotective approach in acute ischemic stroke: a systematic review of clinical and experimental studies publication-title: Brain Circ. doi: 10.4103/bc.bc_52_22 contributor: fullname: Eren – volume: 12 issue: 9 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib11 article-title: Oxidative stress and MicroRNAs in endothelial cells under metabolic disorders publication-title: Cells doi: 10.3390/cells12091341 contributor: fullname: Minjares – volume: 2022 year: 2022 ident: 10.1016/j.biopha.2024.117506_bib48 article-title: Plin5, a new target in diabetic cardiomyopathy publication-title: Oxid. Med. Cell Longev. doi: 10.1155/2022/2122856 contributor: fullname: Cui – volume: 9 issue: 5 year: 2020 ident: 10.1016/j.biopha.2024.117506_bib50 article-title: Novel insights into the role of UBE3A in regulating apoptosis and proliferation publication-title: J. Clin. Med. doi: 10.3390/jcm9051573 contributor: fullname: Simchi – volume: 2021 year: 2021 ident: 10.1016/j.biopha.2024.117506_bib19 article-title: Leonurine ameliorates oxidative stress and insufficient angiogenesis by regulating the PI3K/Akt-eNOS signaling pathway in H(2)O(2)-induced HUVECs publication-title: Oxid. Med Cell Longev. doi: 10.1155/2021/9919466 contributor: fullname: Liao – volume: 17 start-page: 478 issue: 4 year: 2022 ident: 10.1016/j.biopha.2024.117506_bib4 article-title: Global Stroke Fact Sheet 2022 publication-title: Int. J. Stroke: Off. J. Int. Stroke Soc. doi: 10.1177/17474930221080343 contributor: fullname: Corrigendum to: World Stroke Organization (WSO) – volume: 148 year: 2022 ident: 10.1016/j.biopha.2024.117506_bib41 article-title: Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: applications for natural compounds from medicinal herbs publication-title: Biomed. Pharm. doi: 10.1016/j.biopha.2022.112719 contributor: fullname: Zhu – volume: 116 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib24 article-title: Characterization and screening of anti-melanogenesis and anti-photoaging activity of different enzyme-assisted polysaccharide extracts from Portulaca oleracea L. publication-title: Phytomedicine doi: 10.1016/j.phymed.2023.154879 contributor: fullname: Tao – volume: 11 issue: 12 year: 2022 ident: 10.1016/j.biopha.2024.117506_bib38 article-title: Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke publication-title: Antioxidants doi: 10.3390/antiox11122377 contributor: fullname: Wang – volume: 117 start-page: 25800 issue: 41 year: 2020 ident: 10.1016/j.biopha.2024.117506_bib39 article-title: Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.2008762117 contributor: fullname: Lau – volume: 10 start-page: 42 issue: 1 year: 2024 ident: 10.1016/j.biopha.2024.117506_bib8 article-title: Risk factors for intraprocedural hypoxemia in patients with acute cerebral ischemia treated with vascular intervention and its impact on prognosis: a retrospective cohort study publication-title: Brain Circ. doi: 10.4103/bc.bc_50_23 contributor: fullname: Gu – volume: 9 start-page: 38 year: 2019 ident: 10.1016/j.biopha.2024.117506_bib25 article-title: Cardioprotective effects of microRNA-18a on acute myocardial infarction by promoting cardiomyocyte autophagy and suppressing cellular senescence via brain derived neurotrophic factor publication-title: Cell Biosci. doi: 10.1186/s13578-019-0297-8 contributor: fullname: Lin – volume: 167 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib26 article-title: Lyoniresinol attenuates cerebral ischemic stroke injury in MCAO rat based on oxidative stress suppression via regulation of Akt/GSK-3β/Nrf2 signaling publication-title: Biomed. Pharm. doi: 10.1016/j.biopha.2023.115543 contributor: fullname: Guo – volume: 7 issue: 1 year: 2022 ident: 10.1016/j.biopha.2024.117506_bib2 article-title: Primary stroke prevention worldwide: translating evidence into action (vol 7, pg e74, 2022 publication-title: Lancet Public Health contributor: fullname: Owolabi – year: 2000 ident: 10.1016/j.biopha.2024.117506_bib37 article-title: Antioxidant profile and early outcome in stroke patients publication-title: Stroke doi: 10.1161/01.STR.31.10.2295 contributor: fullname: Cherubini – volume: 44 start-page: 1305 issue: 7 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib40 article-title: Angiogenesis after ischemic stroke publication-title: Acta Pharm. Sin. doi: 10.1038/s41401-023-01061-2 contributor: fullname: Fang – volume: 856 year: 2019 ident: 10.1016/j.biopha.2024.117506_bib43 article-title: Ginsenoside Rg1 promotes cerebral angiogenesis via the PI3K/Akt/mTOR signaling pathway in ischemic mice publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2019.172418 contributor: fullname: Chen – volume: 13 year: 2022 ident: 10.1016/j.biopha.2024.117506_bib17 article-title: A review of neuroprotective effects and mechanisms of ginsenosides from panax ginseng in treating ischemic stroke publication-title: Front. Pharm. contributor: fullname: Zhao – volume: 115 start-page: 1343 issue: 8 year: 2019 ident: 10.1016/j.biopha.2024.117506_bib53 article-title: Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvy298 contributor: fullname: Chen – year: 2021 ident: 10.1016/j.biopha.2024.117506_bib34 article-title: Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer publication-title: J. Ginseng Res. contributor: fullname: Lin – volume: 9 start-page: 21 issue: 1 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib3 article-title: Risk factors for multiple recurrent ischemic strokes publication-title: Brain Circ. doi: 10.4103/bc.bc_73_22 contributor: fullname: Uzuner – volume: 19 start-page: 887 issue: 4 year: 2024 ident: 10.1016/j.biopha.2024.117506_bib44 article-title: Sustained release of vascular endothelial growth factor A and basic fibroblast growth factor from nanofiber membranes reduces oxygen/glucose deprivation-induced injury to neurovascular units publication-title: Neural Regen. Res. doi: 10.4103/1673-5374.382252 contributor: fullname: Wu – volume: 30 issue: 5 year: 2021 ident: 10.1016/j.biopha.2024.117506_bib49 article-title: Serum levels of B-cell lymphoma-2 anti-apoptotic protein and malignant middle cerebral artery infarction mortality publication-title: J. Stroke Cereb. Dis. contributor: fullname: Lorente – volume: 167 year: 2023 ident: 10.1016/j.biopha.2024.117506_bib13 article-title: Lyoniresinol attenuates cerebral ischemic stroke injury in MCAO rat based on oxidative stress suppression via regulation of Akt/GSK-3β/Nrf2 signaling publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2023.115543 contributor: fullname: Guo – year: 2020 ident: 10.1016/j.biopha.2024.117506_bib27 article-title: Recent progress in polysaccharides from Panax ginseng C. A. Meyer publication-title: Food Funct. contributor: fullname: Guo – volume: 174 year: 2024 ident: 10.1016/j.biopha.2024.117506_bib31 article-title: Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2024.116625 contributor: fullname: Li – year: 2022 ident: 10.1016/j.biopha.2024.117506_bib42 article-title: Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions publication-title: Signal Transduct. Target. Ther. contributor: fullname: Qin – volume: 115 start-page: 168 issue: 1 year: 2019 ident: 10.1016/j.biopha.2024.117506_bib52 article-title: Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvy157 contributor: fullname: Liu |
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| Title | APMCG-1 attenuates ischemic stroke injury by reducing oxidative stress and apoptosis and promoting angiogenesis via activating PI3K/AKT pathway |
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