Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: II. behavioural characterisation of RG-15 - Gyertyán, István; Sághy, Katalin; Laszy, Judit; Elekes, Ottilia; Kedves, Rita; Gémesi, Larisza I.; Pásztor, Gabriella; Zájer-Balázs, Mária; Kapás, Margit; Ágai Csongor, Éva; Domány, György; Kiss, Béla; et al. (Naunyn-Schmiedeberg's archives of pharmacology, 2008)
Keywords: Animals; Antipsychotic Agents - administration & dosage; Antipsychotic Agents - pharmacokinetics; Antipsychotic Agents - toxicity; Avoidance Learning - drug effects; Benzodiazepines - pharmacology; Biological Availability; Biomedical and Life Sciences; Biomedicine; Catalepsy - chemically induced; Clozapine - pharmacology; Dopamine Antagonists - administration & dosage; Dopamine Antagonists - pharmacokinetics; Dopamine Antagonists - toxicity; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Motor Activity - drug effects; Neurosciences; Original Article; Pharmacology/Toxicology; Pyridines - administration & dosage; Pyridines - pharmacokinetics; Pyridines - toxicity; Rats; Rats, Wistar; Receptors, Dopamine D3 - antagonists & inhibitors; Sulfonamides - administration & dosage; Sulfonamides - pharmacokinetics; Sulfonamides - toxicity; Sulpiride - analogs & derivatives; Sulpiride - pharmacology; Tissue Distribution; Lack of catalepsy; RG-15; Schizophrenia; Antipsychotic; Dopamine D; receptor antagonist; Cognitive improvement