Aloe-Emodin Isolated from Rheum Undulatum L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cells

• Published in: Journal of dietary supplements p. 1
• Main Authors: He, Mei Tong, Nguyen, Quynh Nhu, Cho, Eun Ju, Kim, Seung Hyun, Park, SeonJu, Park, Jun Yeon, Lee, Sullim, Kang, Ki Sung
• Format: Journal Article
• Language: English
• Published: England 03.05.2024
• Subjects: senescence; aloe-emodin; prostate cancer; cell cycle arrest; LNCaP cell

Senescence can promote hyperplastic pathologies, such as cancer. Prostate cancer is the second most common type of cancer in men. The p21-mediate cellular senescence, facilitated through the tumor suppressor p53-dependent pathway, is considered the primary mechanism for cancer treatment. Aloe-emodin...