Remote ischaemic conditioning reduces infarct size in animal in vivo models of ischaemia-reperfusion injury: a systematic review and meta-analysis

• Published in: Cardiovascular research Vol. 113; no. 3; pp. cvw219 - 297
• Main Authors: Bromage, Daniel I., Pickard, Jack M.J., Rossello, Xavier, Ziff, Oliver J., Burke, Niall, Yellon, Derek M., Davidson, Sean M.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2017
• Subjects: Animals; Disease Models, Animal; Editor's Choice; Ischemic Preconditioning - methods; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocardial Infarction - prevention & control; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocardial Reperfusion Injury - prevention & control; Myocardium - metabolism; Myocardium - pathology; Original; Reproducibility of Results; Ischaemia; Infarct size; Reperfusion; Preconditioning; Meta-analysis

The potential of remote ischaemic conditioning (RIC) to ameliorate myocardial ischaemia-reperfusion injury (IRI) remains controversial. We aimed to analyse the pre-clinical evidence base to ascertain the overall effect and variability of RIC in animal in vivo models of myocardial IRI. Furthermore, w...