A Postbiotic Formulation of Lactiplantibacillus plantarum CRL 759 Attenuates Endotoxin Induced Uveitis
To evaluate the anti-inflammatory activity of a cell-free supernatant from CRL 759, in phosphate buffer modified according to Sorensen called POF-759. The activity of POF-759 administered by means of eye drops was evaluated on animals subcutaneously injected with the lipopolysaccharide animals in wh...
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Published in | Ocular immunology and inflammation p. 1 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
09.02.2024
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Abstract | To evaluate the anti-inflammatory activity of a cell-free supernatant from
CRL 759, in phosphate buffer modified according to Sorensen called POF-759.
The activity of POF-759 administered by means of eye drops was evaluated on animals subcutaneously injected with the lipopolysaccharide animals in which uveitis was induced by a subcutaneous injection of lipopolysaccharide (EIU). Clinical signs of ocular inflammation, cytokines and proteins were examined in the aqueous humor. Additionally, cellular infiltration was evaluated by histopathological analysis.
The new postbiotic administered locally decreases signs of ocular damage, the number of infiltrating cells in the anterior and posterior chambers, the proinflammatory mediators and the proteins in the aqueous humor on mice with EIU.
Our results provide an impetus to relieve ocular inflammation and to identify and develop preventive and therapeutic approaches, to avoid deterioration and to maintain healthy eyes on inflammatory processes. |
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AbstractList | To evaluate the anti-inflammatory activity of a cell-free supernatant from
CRL 759, in phosphate buffer modified according to Sorensen called POF-759.
The activity of POF-759 administered by means of eye drops was evaluated on animals subcutaneously injected with the lipopolysaccharide animals in which uveitis was induced by a subcutaneous injection of lipopolysaccharide (EIU). Clinical signs of ocular inflammation, cytokines and proteins were examined in the aqueous humor. Additionally, cellular infiltration was evaluated by histopathological analysis.
The new postbiotic administered locally decreases signs of ocular damage, the number of infiltrating cells in the anterior and posterior chambers, the proinflammatory mediators and the proteins in the aqueous humor on mice with EIU.
Our results provide an impetus to relieve ocular inflammation and to identify and develop preventive and therapeutic approaches, to avoid deterioration and to maintain healthy eyes on inflammatory processes. |
Author | Layús, Bárbara Ivana Rodriguez, Ana Virginia Gómez, María Alejandra Cazorla, Silvia Inés |
Author_xml | – sequence: 1 givenname: Bárbara Ivana surname: Layús fullname: Layús, Bárbara Ivana organization: Centro de Referencia para Lactobacilos (CERELA-CONICET), San Miguel de Tucumán, Argentina – sequence: 2 givenname: María Alejandra surname: Gómez fullname: Gómez, María Alejandra organization: Servicio de Oftalomolgía, Hospital Ángel C. Padilla, San Miguel de Tucumán, Argentina – sequence: 3 givenname: Silvia Inés surname: Cazorla fullname: Cazorla, Silvia Inés organization: Cátedra de Inmunología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina – sequence: 4 givenname: Ana Virginia surname: Rodriguez fullname: Rodriguez, Ana Virginia organization: Centro de Referencia para Lactobacilos (CERELA-CONICET), San Miguel de Tucumán, Argentina |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38335476$$D View this record in MEDLINE/PubMed |
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Keywords | postbiotic Lactiplantibacillus plantarum CRL 759 uveitis Eyes inflammation |
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Title | A Postbiotic Formulation of Lactiplantibacillus plantarum CRL 759 Attenuates Endotoxin Induced Uveitis |
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