Association of paraoxonase-1 (Q192R) gene polymorphism with coronary artery spasm during cardiac catheterisation in Egyptians

• Published in: Archives of physiology and biochemistry Vol. 131; no. 1; p. 33
• Main Authors: Abdelaziz, Tarek A, Mesbah, Noha M, Abo-Elmatty, Dina M, El-Sabbagh, Farah O
• Format: Journal Article
• Language: English
• Published: England 02.01.2025
• Subjects: Aged; Alleles; Aryldialkylphosphatase - blood; Aryldialkylphosphatase - genetics; Cardiac Catheterization - adverse effects; Coronary Angiography; Coronary Vasospasm - blood; Coronary Vasospasm - etiology; Coronary Vasospasm - genetics; Egypt; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; North African People - genetics; Polymorphism, Single Nucleotide; Egypt; Coronary artery spasm (CAS); PON1; Q192R polymorphism

Coronary artery spasm is among the etiology of myocardial infarction. Oxidative stress is involved in the pathogenesis of coronary artery spasm (CAS). Paraoxonase-1 (PON1) is an HDL-bound antioxidant enzyme that protects LDL from oxidative modification. Oxidative-stress-related genetic factors and c...