Inflammation in cerebral ischemia reperfusion improved by avanafil via nod-like receptor protein-3 inflammasome: an experimental study in rats

• Published in: Brain injury p. 1
• Main Authors: Bekmez, Huseyin, Kocak, Mehmet Nuri, Tavaci, Taha, Halici, Hamza, Toktay, Erdem, Celik, Muhammet, Bagci, Hamit Harun
• Format: Journal Article
• Language: English
• Published: England 28.07.2024
• Subjects: ischemia reperfusion; NLRP3; phosphodiesterase-5 inhibitor; rat; Avanafil

The aim of study was to investigate the effect of avanafil, a second-generation phosphodiesterase-5 (PDE5) inhibitor, on cerebral ischemia reperfusion (CI/R) model. 32 male albino Wistar rats were used. Four groups were constituted, as I: the healthy (sham), II: the CI/R group, III: the CI/R +I 10 m...