Unique orbital biphenotypic tumour with neuroendocrine and sebaceous carcinoma features
A 60-year-old female presented with a large, left upper eyelid mass that had rapidly expanded in the 3 months prior to presentation. She had a presumed chalazion excised from the same area 1.5 years ago, but no pathology was investigated. On examination, she had a palpebral mass measuring 4.5 cm x 3...
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| Published in | Orbit (Amsterdam) Vol. 43; no. 1; p. 105 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.02.2024
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| Subjects | |
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| Abstract | A 60-year-old female presented with a large, left upper eyelid mass that had rapidly expanded in the 3 months prior to presentation. She had a presumed chalazion excised from the same area 1.5 years ago, but no pathology was investigated. On examination, she had a palpebral mass measuring 4.5 cm x 3.5 cm that abutted the globe with extensive conjunctival involvement. Neuroimaging demonstrated lesions concerning for parotid gland metastases. An incisional biopsy demonstrated synaptophysin-positive small blue cells concerning for neuroendocrine carcinoma. The patient underwent orbital exenteration with parotidectomy and radical neck dissection. The excised mass was found to have distinct neuroendocrine carcinoma cells intermingled with sebaceous carcinoma cells, a combination not previously reported. |
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| AbstractList | A 60-year-old female presented with a large, left upper eyelid mass that had rapidly expanded in the 3 months prior to presentation. She had a presumed chalazion excised from the same area 1.5 years ago, but no pathology was investigated. On examination, she had a palpebral mass measuring 4.5 cm x 3.5 cm that abutted the globe with extensive conjunctival involvement. Neuroimaging demonstrated lesions concerning for parotid gland metastases. An incisional biopsy demonstrated synaptophysin-positive small blue cells concerning for neuroendocrine carcinoma. The patient underwent orbital exenteration with parotidectomy and radical neck dissection. The excised mass was found to have distinct neuroendocrine carcinoma cells intermingled with sebaceous carcinoma cells, a combination not previously reported. |
| Author | Burgin, Sarah J Campbell, Benjamin C Sun, Jing Klapper, Stephen R Lee, H B Harold Alomari, Ahmed K |
| Author_xml | – sequence: 1 givenname: Jing orcidid: 0000-0001-5366-9080 surname: Sun fullname: Sun, Jing organization: Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA – sequence: 2 givenname: Benjamin C surname: Campbell fullname: Campbell, Benjamin C organization: Oculoplastics, Ascension St. Vincent Hospital, Indianapolis, Indiana, USA – sequence: 3 givenname: Sarah J surname: Burgin fullname: Burgin, Sarah J organization: Department of Otolaryngology-Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA – sequence: 4 givenname: H B Harold surname: Lee fullname: Lee, H B Harold organization: Oculoplastics, Ascension St. Vincent Hospital, Indianapolis, Indiana, USA – sequence: 5 givenname: Ahmed K surname: Alomari fullname: Alomari, Ahmed K organization: Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA – sequence: 6 givenname: Stephen R surname: Klapper fullname: Klapper, Stephen R organization: Klapper Eyelid and Facial Plastic Surgery, Indianapolis, Indiana, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35635143$$D View this record in MEDLINE/PubMed |
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| Keywords | neuroendocrine carcinoma sebaceous cell carcinoma orbital tumor Biphenotypic orbital tumor |
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| Snippet | A 60-year-old female presented with a large, left upper eyelid mass that had rapidly expanded in the 3 months prior to presentation. She had a presumed... |
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| SubjectTerms | Adenocarcinoma, Sebaceous - diagnostic imaging Adenocarcinoma, Sebaceous - pathology Adenocarcinoma, Sebaceous - surgery Carcinoma, Neuroendocrine - diagnostic imaging Carcinoma, Neuroendocrine - surgery Eyelid Neoplasms - pathology Female Humans Middle Aged Orbital Neoplasms - diagnostic imaging Orbital Neoplasms - surgery Sebaceous Gland Neoplasms - diagnostic imaging Sebaceous Gland Neoplasms - surgery |
| Title | Unique orbital biphenotypic tumour with neuroendocrine and sebaceous carcinoma features |
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