Chronic kidney disease and physiologically based pharmacokinetic modeling: a critical review of existing models

• Published in: Expert opinion on drug metabolism & toxicology Vol. 20; no. 1-2; p. 95
• Main Authors: Zamir, Ammara, Alqahtani, Faleh, Rasool, Muhammad Fawad
• Format: Journal Article
• Language: English
• Published: England 2024
• Subjects: Child; Computer Simulation; Glomerular Filtration Rate; Humans; Models, Biological; Renal Insufficiency, Chronic; pharmacokinetics; renal clearance; model evaluation; Chronic kidney disease (CKD); physiologically based pharmacokinetic modeling (PBPK); pathophysiology

Physiologically based pharmacokinetic (PBPK) modeling is a paradigm shift in this era for determining the exposure of drugs in pediatrics, geriatrics, and patients with chronic diseases where clinical trials are difficult to conduct. This review has collated data regarding published PBPK models on c...