Methotrexate polyglutamates

• Published in: Expert review of clinical pharmacology Vol. 17; no. 11; p. 1025
• Main Authors: Yang, Zhilin, Mo, Jiayi, Li, Wenshu, Zhao, Zhigang, Mei, Shenghui
• Format: Journal Article
• Language: English
• Published: England 01.11.2024
• Subjects: Animals; Antirheumatic Agents - administration & dosage; Antirheumatic Agents - adverse effects; Antirheumatic Agents - pharmacokinetics; Antirheumatic Agents - pharmacology; Humans; Methotrexate - administration & dosage; Methotrexate - adverse effects; Methotrexate - analogs & derivatives; Methotrexate - pharmacokinetics; Methotrexate - pharmacology; Polyglutamic Acid - analogs & derivatives; Polyglutamic Acid - pharmacology; Precision Medicine; toxicity; pharmacokinetics; Analytical methods; methotrexate polyglutamates; efficacy

Methotrexate polyglutamates (MTXPGs) are intracellular metabolites of methotrexate (MTX) that play a critical role in the drug's activity, influencing both its efficacy and toxicity. As the exact implications of MTXPGs in these processes remain a subject of debate, a comprehensive review of MTX...