The natural sesquiterpene lactone inulicin suppresses the production of pro-inflammatory mediators via inhibiting NF-κB and AP-1 pathways in LPS-activated macrophages

• Published in: Immunopharmacology and immunotoxicology Vol. 46; no. 5; p. 583
• Main Authors: Yan, Jingjing, Cai, Min, Zang, Chenchen, Li, Wenjing, Liu, Zhuangzhuang, Li, Ximeng, Gao, Yuan, Qi, Yun
• Format: Journal Article
• Language: English
• Published: England 01.10.2024
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - metabolism; Lactones - pharmacology; Lipopolysaccharides - pharmacology; Lipopolysaccharides - toxicity; Macrophages - drug effects; Macrophages - metabolism; Male; Mice; NF-kappa B - metabolism; RAW 264.7 Cells; Sesquiterpenes - pharmacology; Signal Transduction - drug effects; Transcription Factor AP-1 - metabolism; NF-κB; Inulicin; JNK; endotoxemia; macrophage; anti-inflammation; AP-1; LPS; ERK

Inulicin is a sesquiterpene lactone in Inulae Flos which is clinically used for the treatment of inflammatory diseases, such as cough, sputum production, and vomiting. This study aimed to demonstrate the anti-inflammatory activity and the underlying mechanism of inulicin by using lipopolysaccharide...