Oncostatin M promotes epithelial barrier dysfunction in patients with eosinophilic chronic rhinosinusitis with nasal polyps

• Published in: Tissue barriers p. 2399235
• Main Authors: Wang, Bao-Feng, Wang, Ying-Ying, Lin, Hai, Yi, Yun-Lan
• Format: Journal Article
• Language: English
• Published: United States 03.09.2024
• Subjects: occludin; eosinophilic chronic rhinosinusitis with nasal polyps; MMP-1; OSM; OSMRβ; MMP-7; nasal epithelial cells

Oncostatin M (OSM) may be involved in the promotion of mucosal epithelial barrier dysfunction in patients with eosinophilic chronic rhinosinusitis with nasal polyps (Eos CRSwNP) by inducing matrix metalloproteinase (MMP) -1 and -7. The aim was to evaluate the roles and mechanisms of action of OSM on...