Eyelid skin and fibroadipose tissue MMP-1, MMP-3, TNF-α, and IL-6 levels in patients with inactive moderate-to-severe Graves' orbitopathy

• Published in: Orbit (Amsterdam) Vol. 44; no. 2; p. 190
• Main Authors: Yuksel, Nilay, Ozel-Turkcu, Ummuhani, Gok, Muslum, Saritas, Ozge, Yazici, Bulent
• Format: Journal Article
• Language: English
• Published: England 01.04.2025
• Subjects: Adipose Tissue - enzymology; Adipose Tissue - metabolism; Adult; Blepharoplasty; Enzyme-Linked Immunosorbent Assay; Eyelids - metabolism; Eyelids - surgery; Female; Graves Ophthalmopathy - metabolism; Graves Ophthalmopathy - surgery; Humans; Interleukin-6 - metabolism; Male; Matrix Metalloproteinase 1 - metabolism; Matrix Metalloproteinase 3 - metabolism; Middle Aged; Prospective Studies; Skin - enzymology; Skin - metabolism; Tumor Necrosis Factor-alpha - metabolism; Extracellular matrix; fibrosis; tissue remodeling; matrix metalloproteinases; pro-inflammatory cytokines

To evaluate matrix metalloprotease-1 (MMP-1), matrix metalloprotease-3 (MMP-3), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) levels in the eyelid skin and fibroadipose tissue in patients with inactive moderate-to-severe Graves' orbitopathy (GO). This prospective study included...