Modulation of carcinoembryonic antigen release by glucosylceramide--implications for HT29 cell differentiation

• Published in: European journal of biochemistry Vol. 258; no. 1; pp. 233 - 242
• Main Authors: Babia, T, Veldman, R J, Hoekstra, D, Kok, J W
• Format: Journal Article
• Language: English
• Published: England 15.11.1998
• Subjects: Carcinoembryonic Antigen - metabolism; Cell Differentiation; Glucosylceramides - antagonists & inhibitors; Glucosylceramides - biosynthesis; Glucosylceramides - physiology; HT29 Cells; Humans

Previous work suggested that glucosylceramide (GlcCer) plays a role in the regulation of cell differentiation of HT29 human colon tumor cells. In the present study, we investigated the role of GlcCer in the cellular release of carcinoembryonic antigen (CEA), a marker for cell differentiation. This w...