Interpenetrating Polymer Networks in Biomedical Fields: Recent Advanced and Applications
ABSTRACT Recent developments in polymer materials have led to an increased implementation of hydrogels in biomedical settings, especially in the creation of smart hydrogels. Traditional single‐network hydrogels often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility...
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| Published in | Polymers for advanced technologies Vol. 36; no. 2 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.02.2025
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | ABSTRACT
Recent developments in polymer materials have led to an increased implementation of hydrogels in biomedical settings, especially in the creation of smart hydrogels. Traditional single‐network hydrogels often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility, and slow response rates. To address these issues, researchers have introduced Interpenetrating Polymer Network (IPN) hydrogels, which significantly improve mechanical strength via topological entanglements and physical interactions. This dual‐network design not only enhances biocompatibility but also responsiveness to stimuli, endowing the hydrogels with distinctive properties like cell adhesion, conductivity, hemostatic functions, antioxidant abilities, and color‐changing properties. The purpose of this article is to elucidate the factors that trigger stimuli responsiveness in IPN hydrogels, their impacts on cellular behavior, and the various biomedical applications they can serve. A comprehensive overview is provided regarding their classification, mechanisms, performance attributes, and related subjects. Ultimately, this review emphasizes the promise that smart IPN hydrogels hold in fulfilling the increasing need for innovative materials with improved mechanical features and biocompatibility in the biomedical sector. |
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| AbstractList | ABSTRACT
Recent developments in polymer materials have led to an increased implementation of hydrogels in biomedical settings, especially in the creation of smart hydrogels. Traditional single‐network hydrogels often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility, and slow response rates. To address these issues, researchers have introduced Interpenetrating Polymer Network (IPN) hydrogels, which significantly improve mechanical strength via topological entanglements and physical interactions. This dual‐network design not only enhances biocompatibility but also responsiveness to stimuli, endowing the hydrogels with distinctive properties like cell adhesion, conductivity, hemostatic functions, antioxidant abilities, and color‐changing properties. The purpose of this article is to elucidate the factors that trigger stimuli responsiveness in IPN hydrogels, their impacts on cellular behavior, and the various biomedical applications they can serve. A comprehensive overview is provided regarding their classification, mechanisms, performance attributes, and related subjects. Ultimately, this review emphasizes the promise that smart IPN hydrogels hold in fulfilling the increasing need for innovative materials with improved mechanical features and biocompatibility in the biomedical sector. Recent developments in polymer materials have led to an increased implementation of hydrogels in biomedical settings, especially in the creation of smart hydrogels. Traditional single‐network hydrogels often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility, and slow response rates. To address these issues, researchers have introduced Interpenetrating Polymer Network (IPN) hydrogels, which significantly improve mechanical strength via topological entanglements and physical interactions. This dual‐network design not only enhances biocompatibility but also responsiveness to stimuli, endowing the hydrogels with distinctive properties like cell adhesion, conductivity, hemostatic functions, antioxidant abilities, and color‐changing properties. The purpose of this article is to elucidate the factors that trigger stimuli responsiveness in IPN hydrogels, their impacts on cellular behavior, and the various biomedical applications they can serve. A comprehensive overview is provided regarding their classification, mechanisms, performance attributes, and related subjects. Ultimately, this review emphasizes the promise that smart IPN hydrogels hold in fulfilling the increasing need for innovative materials with improved mechanical features and biocompatibility in the biomedical sector. |
| Author | Afshar Taromi, Arsia Shahi, Farangis Zarei, Sara Khonakdar, Hossein Ali Afshar, Hana Salah Othman, Razhan Kamran, Farimah |
| Author_xml | – sequence: 1 givenname: Farangis orcidid: 0009-0007-1591-4998 surname: Shahi fullname: Shahi, Farangis organization: Amirkabir University of Technology – sequence: 2 givenname: Sara surname: Zarei fullname: Zarei, Sara organization: Iran Polymer and Petrochemical Institute – sequence: 3 givenname: Razhan surname: Salah Othman fullname: Salah Othman, Razhan organization: Knowledge University – sequence: 4 givenname: Hana surname: Afshar fullname: Afshar, Hana organization: Amirkabir University of Technology – sequence: 5 givenname: Farimah surname: Kamran fullname: Kamran, Farimah organization: Amirkabir University of Technology – sequence: 6 givenname: Arsia surname: Afshar Taromi fullname: Afshar Taromi, Arsia email: arsia.afshar@ippi.ac.ir organization: Iran Polymer and Petrochemical Institute – sequence: 7 givenname: Hossein Ali orcidid: 0000-0001-8143-9338 surname: Khonakdar fullname: Khonakdar, Hossein Ali email: hakhonakdar@gmail.com organization: Iran Polymer and Petrochemical Institute |
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Recent developments in polymer materials have led to an increased implementation of hydrogels in biomedical settings, especially in the creation of... Recent developments in polymer materials have led to an increased implementation of hydrogels in biomedical settings, especially in the creation of smart... |
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| SubjectTerms | Biocompatibility biomedical applications Biomedical materials biosensors Cell adhesion Hydrogels Interpenetrating networks interpenetrating polymer network Network design Polymers smart polymers Stimuli |
| Title | Interpenetrating Polymer Networks in Biomedical Fields: Recent Advanced and Applications |
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