Long-Term Therapy with Lenalidomide in a Patient with POEMS Syndrome

Lenalidomide is an effective therapy against malignant plasma cells and a potent agent against proinflammatory and proangiogenic cytokines. The use of lenalidomide in POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein with plasma cells, skin changes) has been reported, but its b...

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Published inEuropean journal of case reports in internal medicine Vol. 1; no. 1
Main Authors Chu, Benjamin F, Shana'ah, Arwa, Hofmeister, Craig C, Benson, Don M, Sell, Megan, Tucker, Jill, Pichiorri, Flavia, Efebera, Yvonne A
Format Journal Article
LanguageEnglish
Published Italy SMC MEDIA SRL 01.01.2014
Subjects
lenalidomide, POEMS
POEMS
Lenalidomide
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Abstract Lenalidomide is an effective therapy against malignant plasma cells and a potent agent against proinflammatory and proangiogenic cytokines. The use of lenalidomide in POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein with plasma cells, skin changes) has been reported, but its benefit in long-term use is not well established. A 55-year-old man with POEMS and debilitating polyneuropathy was treated with lenalidomide and dexamethasone followed by maintenance lenalidomide. He remains in haematologic remission and in complete recovery of functional status 3.5 years after diagnosis. This case supports the long-term use of lenalidomide in patients with POEMS syndrome.
AbstractList Lenalidomide is an effective therapy against malignant plasma cells and a potent agent against proinflammatory and proangiogenic cytokines. The use of lenalidomide in POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein with plasma cells, skin changes) has been reported, but its benefit in long-term use is not well established. A 55-year-old man with POEMS and debilitating polyneuropathy was treated with lenalidomide and dexamethasone followed by maintenance lenalidomide. He remains in haematologic remission and in complete recovery of functional status 3.5 years after diagnosis. This case supports the long-term use of lenalidomide in patients with POEMS syndrome.
Author Tucker, Jill
Sell, Megan
Pichiorri, Flavia
Shana'ah, Arwa
Benson, Don M
Chu, Benjamin F
Efebera, Yvonne A
Hofmeister, Craig C
AuthorAffiliation a Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, United States
b Department of Pathology, Ohio State University, Columbus, OH, United States
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Title Long-Term Therapy with Lenalidomide in a Patient with POEMS Syndrome
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