Leiomyosarcoma: Lung Metastasis
Uterine leiomyosarcoma distant metastasis is common, and lung metastasis has been reported. However, unique cases have been identified either with late onset of metastatic disease or with large size of lung metastasis. A typical approach to avoid metastasis would be a hysterectomy. Nonetheless, meta...
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Published in | Curēus (Palo Alto, CA) Vol. 15; no. 1; p. e34373 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Springer Nature B.V
01.01.2023
Cureus |
Subjects | |
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Abstract | Uterine leiomyosarcoma distant metastasis is common, and lung metastasis has been reported. However, unique cases have been identified either with late onset of metastatic disease or with large size of lung metastasis. A typical approach to avoid metastasis would be a hysterectomy. Nonetheless, metastatic recurrence is common. We encountered a case at our hospital with leiomyosarcoma metastatic to the lungs. Lung metastasis was noted to be 17 cm in diameter. This size has not yet been reported in the literature to the best of our knowledge. |
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AbstractList | Uterine leiomyosarcoma distant metastasis is common, and lung metastasis has been reported. However, unique cases have been identified either with late onset of metastatic disease or with large size of lung metastasis. A typical approach to avoid metastasis would be a hysterectomy. Nonetheless, metastatic recurrence is common. We encountered a case at our hospital with leiomyosarcoma metastatic to the lungs. Lung metastasis was noted to be 17 cm in diameter. This size has not yet been reported in the literature to the best of our knowledge.Uterine leiomyosarcoma distant metastasis is common, and lung metastasis has been reported. However, unique cases have been identified either with late onset of metastatic disease or with large size of lung metastasis. A typical approach to avoid metastasis would be a hysterectomy. Nonetheless, metastatic recurrence is common. We encountered a case at our hospital with leiomyosarcoma metastatic to the lungs. Lung metastasis was noted to be 17 cm in diameter. This size has not yet been reported in the literature to the best of our knowledge. Uterine leiomyosarcoma distant metastasis is common, and lung metastasis has been reported. However, unique cases have been identified either with late onset of metastatic disease or with large size of lung metastasis. A typical approach to avoid metastasis would be a hysterectomy. Nonetheless, metastatic recurrence is common. We encountered a case at our hospital with leiomyosarcoma metastatic to the lungs. Lung metastasis was noted to be 17 cm in diameter. This size has not yet been reported in the literature to the best of our knowledge. |
Author | Ilyas, Usman Baig, Muhammad A Makhoul, Karim Hosna, Asma Miller, Daniel |
AuthorAffiliation | 4 Internal Medicine, Mount Sinai Hospital, New York, USA 5 Medicine, Mount Sinai Hospital, New York, USA 3 Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA 2 Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Queens, USA 1 Neurology, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Queens, USA |
AuthorAffiliation_xml | – name: 3 Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA – name: 5 Medicine, Mount Sinai Hospital, New York, USA – name: 2 Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Queens, USA – name: 1 Neurology, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Queens, USA – name: 4 Internal Medicine, Mount Sinai Hospital, New York, USA |
Author_xml | – sequence: 1 givenname: Karim surname: Makhoul fullname: Makhoul, Karim – sequence: 2 givenname: Daniel surname: Miller fullname: Miller, Daniel – sequence: 3 givenname: Usman surname: Ilyas fullname: Ilyas, Usman – sequence: 4 givenname: Asma surname: Hosna fullname: Hosna, Asma – sequence: 5 givenname: Muhammad A surname: Baig fullname: Baig, Muhammad A |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36874734$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/s1470-2045(22)00380-1 10.1200/JCO.2006.10.4117 10.1016/S1470-2045(17)30381-9 10.1200/JGO.2015.002089 10.1016/j.ygyno.2004.11.036 10.1200/JCO.2017.75.9845 10.1016/j.clon.2012.11.008 10.7556/jom_2010_04.0001 10.1016/0002-9378(79)90841-X 10.1097/00000478-200204000-00005 10.1007/s10555-006-8502-8 10.1510/icvts.2009.218743 10.1155/2014/961675 10.1006/gyno.1993.1084 |
ContentType | Journal Article |
Copyright | Copyright © 2023, Makhoul et al. Copyright © 2023, Makhoul et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2023, Makhoul et al. 2023 Makhoul et al. |
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Keywords | leiomyosarcoma lung metastasis pleural effusion uterine cancer hydronephrosis |
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References_xml | – volume: 78 year: 1986 ident: ref7 article-title: Unilateral giant lung metastasis of uterine leiomyosarcoma: diagnostic pitfalls in an unusual case publication-title: J Natl Med Assoc – volume: 23 year: 2022 ident: ref10 article-title: Doxorubicin alone versus doxorubicin with trabectedin followed by trabectedin alone as first-line therapy for metastatic or unresectable leiomyosarcoma (LMS- 04): a randomised, multicentre, open-label phase 3 trial publication-title: Lancet Oncol doi: 10.1016/s1470-2045(22)00380-1 – volume: 25 year: 2007 ident: ref13 article-title: Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002 [corrected] publication-title: J Clin Oncol doi: 10.1200/JCO.2006.10.4117 – volume: 18 year: 2017 ident: ref11 article-title: Doxorubicin plus evofosfamide versus doxorubicin alone in locally advanced, unresectable or metastatic soft-tissue sarcoma (TH CR-406/SARC021): an international, multicentre, open-label, randomised phase 3 trial publication-title: Lancet Oncol doi: 10.1016/S1470-2045(17)30381-9 – volume: 2 year: 2016 ident: ref2 article-title: Pulmonary nodules in patients with nonpulmonary cancer: not always metastases publication-title: J Glob Oncol doi: 10.1200/JGO.2015.002089 – volume: 96 year: 2005 ident: ref12 article-title: Phase II evaluation of liposomal doxorubicin (Doxil) in recurrent or advanced leiomyosarcoma of the uterus: a Gynecologic Oncology Group study publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2004.11.036 – volume: 36 year: 2018 ident: ref4 article-title: Soft tissue and uterine leiomyosarcoma publication-title: J Clin Oncol doi: 10.1200/JCO.2017.75.9845 – volume: 25 year: 2013 ident: ref9 article-title: Systematic chemotherapy for inoperable, locally advanced, recurrent, or metastatic uterine leiomyosarcoma: a systematic review publication-title: Clin Oncol (R Coll Radiol) doi: 10.1016/j.clon.2012.11.008 – volume: 110 year: 2010 ident: ref3 article-title: Diagnosis and management of primary pulmonary leiomyosarcoma publication-title: J Am Osteopath Assoc doi: 10.7556/jom_2010_04.0001 – volume: 134 year: 1979 ident: ref5 article-title: Uterine leiomyosarcoma: a review of prognostic clinical and pathologic features publication-title: Am J Obstet Gynecol doi: 10.1016/0002-9378(79)90841-X – volume: 26 year: 2002 ident: ref8 article-title: Endometrial stromal sarcoma metastatic to the lung: a detailed analysis of 16 patients publication-title: Am J Surg Pathol doi: 10.1097/00000478-200204000-00005 – volume: 25 year: 2006 ident: ref1 article-title: Clinical patterns of metastasis publication-title: Cancer Metastasis Rev doi: 10.1007/s10555-006-8502-8 – volume: 9 year: 2009 ident: ref15 article-title: Feasibility of ablation as an alternative to surgical metastasectomy in patients with unresectable sarcoma pulmonary metastases publication-title: Interact Cardiovasc Thorac Surg doi: 10.1510/icvts.2009.218743 – volume: 2014 year: 2014 ident: ref6 article-title: Lung metastasis after an eighteen-years-long disease-free period since uterine leiomyosarcoma diagnosis publication-title: Case Rep Oncol Med doi: 10.1155/2014/961675 – volume: 49 year: 1993 ident: ref14 article-title: Phase II study of ifosfamide and mesna in nonsquamous carcinoma of the cervix: a Gynecologic Oncology Group study publication-title: Gynecol Oncol doi: 10.1006/gyno.1993.1084 |
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SubjectTerms | Abdomen Asymptomatic Chemotherapy Disease Dyspnea Hematology Hospitals Hysterectomy Internal medicine Lung cancer Lungs Medical prognosis Medicine Metastasis Patients Pulmonology Radiation therapy Radiology Smooth muscle Tomography Tumors Uterine cancer Uterus |
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Title | Leiomyosarcoma: Lung Metastasis |
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