Efficacy and safety of naldemedine for opioid-induced constipation in older patients with cancer: a retrospective study

• Published in: European journal of gastroenterology & hepatology Vol. 36; no. 5; p. 571
• Main Authors: Imai, Hisao, Fujita, Yukiyoshi, Hiruta, Eriko, Masuno, Takashi, Yamazaki, Shigeki, Tanaka, Hajime, Kamiya, Teruhiko, Sandoh, Mitsuru, Takei, Satoshi, Arai, Kazuya, Nishiba, Hiromi, Mogi, Junnosuke, Koizuka, Shiro, Saito, Taeko, Obayashi, Kyoko, Kaira, Kyoichi, Minato, Koichi
• Format: Journal Article
• Language: English
• Published: England 01.05.2024
• Subjects: Aged; Analgesics, Opioid - adverse effects; Constipation - chemically induced; Constipation - drug therapy; Humans; Naltrexone - analogs & derivatives; Neoplasms - complications; Neoplasms - drug therapy; Opioid-Induced Constipation - drug therapy; Retrospective Studies

Opioids are pain relievers that are often associated with opioid-induced constipation (OIC) that worsens with age. We performed a multicenter, retrospective analysis on the efficacy and safety of naldemedine, an opioid receptor antagonist, in treating OIC in patients with cancer (age >75 years)....