Vascular infarction by subcutaneous application of tissue factor targeted to tumor vessels with NGR-peptides: Activity and toxicity profile

• Published in: International journal of oncology Vol. 37; no. 6; pp. 1389 - 1397
• Main Authors: DREISCHALÜCK, Johannes, SCHWÖPPE, Christian, MESTERS, Rolf M, BERDEL, Wolfgang E, SPIEKER, Tilmann, KESSLER, Torsten, TIEMANN, Klaus, LIERSCH, Ruediger, SCHLIEMANN, Christoph, KREUTER, Michael, KOLKMEYER, Astrid, HINTELMANN, Heike
• Format: Journal Article
• Language: English
• Published: Athens Editorial Academy of the International Journal of Oncology 01.12.2010
• Subjects: Angiogenesis Inhibitors - administration & dosage; Angiogenesis Inhibitors - adverse effects; Animals; Biological and medical sciences; Blood Vessels - drug effects; Blood Vessels - pathology; Cell Line, Tumor; Cells, Cultured; Drug Delivery Systems - methods; Humans; Infarction - chemically induced; Injections, Subcutaneous; Medical sciences; Mice; Mice, Nude; Neoplasms - blood supply; Neoplasms - drug therapy; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - pathology; Oligopeptides - administration & dosage; Oligopeptides - adverse effects; Oligopeptides - chemistry; Recombinant Fusion Proteins - administration & dosage; Recombinant Fusion Proteins - adverse effects; Recombinant Fusion Proteins - chemistry; Thromboplastin - administration & dosage; Thromboplastin - adverse effects; Thromboplastin - chemistry; Tumors; Xenograft Model Antitumor Assays; Targeting; Infarct; Peptides; Subcutaneous; Toxicity; Tumoral tissue; Tissue factor; Malignant tumor; subcutaneous therapy; vascular targeting; truncated tissue factor; Biological activity; tumor-homing peptides; Cancerology; Treatment; Blood vessel; Truncated shape; Homing phenomenon; Circulatory system; Subcutaneous tissue; Cancer

tTF-NGR consists of the extracellular domain of the (truncated) tissue factor (tTF), a central molecule for coagulation in vivo, and the peptide GNGRAHA (NGR), a ligand of the surface protein aminopeptidase N (CD13). After deamidation of the NGR-peptide moiety, the fusion protein is also a ligand fo...