Clonal Kinetics and Single-Cell Transcriptional Profiles of T Cells Mobilized to Blood by Acute Exercise

• Published in: Medicine and science in sports and exercise Vol. 55; no. 6; p. 991
• Main Authors: Zúñiga, Tiffany M, Baker, Forrest L, Smith, Kyle A, Batatinha, Helena, Lau, Branden, Burgess, Shane C, Gustafson, Michael P, Katsanis, Emmanuel, Simpson, Richard J
• Format: Journal Article
• Language: English
• Published: United States 01.06.2023
• Subjects: Clone Cells - metabolism; Epstein-Barr Virus Infections - metabolism; Exercise; Herpesvirus 4, Human - metabolism; Humans; Leukocytes, Mononuclear - metabolism; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - metabolism; Receptors, Antigen, T-Cell, alpha-beta - genetics; Receptors, Antigen, T-Cell, alpha-beta - metabolism; T-Lymphocytes

Acute exercise redistributes large numbers of memory T cells, which may contribute to enhanced immune surveillance in regular exercisers. It is not known, however, if acute exercise promotes a broad or oligoclonal T-cell receptor (TCR) repertoire or evokes transcriptomic changes in "exercise-re...