Association of β-Amyloid, Microglial Activation, Cortical Thickness, and Metabolism in Older Adults Without Dementia

• Published in: Neurology Vol. 102; no. 7; p. e209205
• Main Authors: Cai, Yue, Shi, Dai, Lan, Guoyu, Chen, Linting, Jiang, Yanni, Zhou, Liemin, Guo, Tengfei
• Format: Journal Article
• Language: English
• Published: United States 09.04.2024
• Subjects: Aged; Alzheimer Disease - metabolism; Amyloid beta-Peptides - metabolism; Amyloidosis; Biomarkers; Cognitive Dysfunction - metabolism; Female; Glucose; Humans; Male; Microglia - metabolism; Peptide Fragments; Positron-Emission Tomography - methods; tau Proteins

Plasma β-amyloid (Aβ )/Aβ levels have shown promise in identifying Aβ-PET positive individuals. This study explored the concordance and discordance of plasma Aβ /Aβ positivity (Plasma±) with CSF Aβ /Aβ positivity (CSF±) and Aβ-PET positivity (PET±) in older adults without dementia. Associations of A...