Optimizing Surgical Planning for Epilepsy Patients With Multimodal Neuroimaging and Neurophysiology Integration: A Case Study

• Published in: Journal of clinical neurophysiology Vol. 41; no. 4; p. 317
• Main Authors: Gong, Ruxue, Bickel, Stephan, Tostaeva, Gelana, Lado, Fred A, Metha, Ashesh D, Kuzniecky, Ruben I, Bonilha, Leonardo F, Gleichgerrcht, Ezequiel L
• Format: Journal Article
• Language: English
• Published: United States 01.05.2024
• Subjects: Adult; Brain - diagnostic imaging; Brain - physiopathology; Brain - surgery; Diffusion Tensor Imaging; Electroencephalography - methods; Epilepsy - diagnostic imaging; Epilepsy - physiopathology; Epilepsy - surgery; Epilepsy, Frontal Lobe - diagnostic imaging; Epilepsy, Frontal Lobe - physiopathology; Epilepsy, Frontal Lobe - surgery; Female; Humans; Magnetic Resonance Imaging - methods; Male; Multimodal Imaging; Neuroimaging - methods
• DOI: 10.1097/WNP.0000000000001071

Current preoperative evaluation of epilepsy can be challenging because of the lack of a comprehensive view of the network's dysfunctions. To demonstrate the utility of our multimodal neurophysiology and neuroimaging integration approach in the presurgical evaluation, we present a proof-of-concept for using this approach in a patient with nonlesional frontal lobe epilepsy who underwent two resective surgeries to achieve seizure control. We conducted a post-hoc investigation using four neuroimaging and neurophysiology modalities: diffusion tensor imaging, resting-state functional MRI, and stereoelectroencephalography at rest and during seizures. We computed region-of-interest-based connectivity for each modality and applied betweenness centrality to identify key network hubs across modalities. Our results revealed that despite seizure semiology and stereoelectroencephalography indicating dysfunction in the right orbitofrontal region, the maximum overlap on the hubs across modalities extended to right temporal areas. Notably, the right middle temporal lobe region served as an overlap hub across diffusion tensor imaging, resting-state functional MRI, and rest stereoelectroencephalography networks and was only included in the resected area in the second surgery, which led to long-term seizure control of this patient. Our findings demonstrated that transmodal hubs could help identify key areas related to epileptogenic network. Therefore, this case presents a promising perspective of using a multimodal approach to improve the presurgical evaluation of patients with epilepsy.