Breast mucoepidermoid carcinoma with a rare CRTC3–MAML2 fusion

Mucoepidermoid carcinoma is the most prevalent malignancy in the salivary gland and is sporadic in the breast. Here, we report a case of breast mucoepidermoid carcinoma with a rare CREB-regulated transcription coactivator 3–mastermind-like transcriptional coactivator 2 ( CRTC3–MAML2 ) fusion. A 23-y...

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Published inInternational cancer conference journal Vol. 13; no. 4; pp. 481 - 487
Main Authors Kawaguchi, Kana, Ijichi, Hideki, Ueo, Hiroki, Hisamatsu, Yuichi, Omori, Sachie, Shigechi, Tomoko, Kawaguchi, Kengo, Yamamoto, Hidetaka, Oda, Yoshinao, Kubo, Makoto, Yoshizumi, Tomoharu
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 01.10.2024
Springer Nature B.V
Subjects
Biopsy
Breast cancer
Breast carcinoma
Cancer therapies
Case report - Pathology
Case reports
Cell proliferation
Chemotherapy
Cyclic AMP response element-binding protein
Cytoplasm
Endocrine therapy
Exocrine glands
Genetic analysis
Histology
Leukocytes (eosinophilic)
Lymphatic system
Malignancy
Mammography
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Metastasis
Oncology
Polymerase chain reaction
Proteins
Radiation therapy
Reverse transcription
Salivary gland
Stains & staining
Surgical Oncology
Tumors
Ultrasonic imaging
fusion
Breast cancer
Mucoepidermoid carcinoma
Gene rearrangement
CRTC3–MAML2 fusion
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Abstract Mucoepidermoid carcinoma is the most prevalent malignancy in the salivary gland and is sporadic in the breast. Here, we report a case of breast mucoepidermoid carcinoma with a rare CREB-regulated transcription coactivator 3–mastermind-like transcriptional coactivator 2 ( CRTC3–MAML2 ) fusion. A 23-year-old female was admitted to our hospital with a left breast palpable mass. Histologic findings of the core-needle biopsy indicated breast cancer. The section revealed a squamoid tumor-cell proliferation with enlarged nuclei and eosinophilic cytoplasm among smaller intermediate cells and abundant cystic spaces containing secretory materials. The features were compatible with mucoepidermoid carcinoma in low-grade, confirmed by detecting the CRTC3–MAML2 fusion using reverse transcription polymerase chain reaction and direct sequencing. We only administered tamoxifen postoperatively without other adjuvant therapy because her tumor partially expressed hormonal receptors. No signs indicate a recurrence or metastasis in our over 3 year follow-up. The genetic analysis helps in definitively diagnosing breast mucoepidermoid carcinoma, and the treatment strategy should be considered based on the histologic findings.
AbstractList Mucoepidermoid carcinoma is the most prevalent malignancy in the salivary gland and is sporadic in the breast. Here, we report a case of breast mucoepidermoid carcinoma with a rare CREB-regulated transcription coactivator 3-mastermind-like transcriptional coactivator 2 ( ) fusion. A 23-year-old female was admitted to our hospital with a left breast palpable mass. Histologic findings of the core-needle biopsy indicated breast cancer. The section revealed a squamoid tumor-cell proliferation with enlarged nuclei and eosinophilic cytoplasm among smaller intermediate cells and abundant cystic spaces containing secretory materials. The features were compatible with mucoepidermoid carcinoma in low-grade, confirmed by detecting the fusion using reverse transcription polymerase chain reaction and direct sequencing. We only administered tamoxifen postoperatively without other adjuvant therapy because her tumor partially expressed hormonal receptors. No signs indicate a recurrence or metastasis in our over 3 year follow-up. The genetic analysis helps in definitively diagnosing breast mucoepidermoid carcinoma, and the treatment strategy should be considered based on the histologic findings.
Mucoepidermoid carcinoma is the most prevalent malignancy in the salivary gland and is sporadic in the breast. Here, we report a case of breast mucoepidermoid carcinoma with a rare CREB-regulated transcription coactivator 3–mastermind-like transcriptional coactivator 2 (CRTC3–MAML2) fusion. A 23-year-old female was admitted to our hospital with a left breast palpable mass. Histologic findings of the core-needle biopsy indicated breast cancer. The section revealed a squamoid tumor-cell proliferation with enlarged nuclei and eosinophilic cytoplasm among smaller intermediate cells and abundant cystic spaces containing secretory materials. The features were compatible with mucoepidermoid carcinoma in low-grade, confirmed by detecting the CRTC3–MAML2 fusion using reverse transcription polymerase chain reaction and direct sequencing. We only administered tamoxifen postoperatively without other adjuvant therapy because her tumor partially expressed hormonal receptors. No signs indicate a recurrence or metastasis in our over 3 year follow-up. The genetic analysis helps in definitively diagnosing breast mucoepidermoid carcinoma, and the treatment strategy should be considered based on the histologic findings.
Mucoepidermoid carcinoma is the most prevalent malignancy in the salivary gland and is sporadic in the breast. Here, we report a case of breast mucoepidermoid carcinoma with a rare CREB-regulated transcription coactivator 3–mastermind-like transcriptional coactivator 2 ( CRTC3–MAML2 ) fusion. A 23-year-old female was admitted to our hospital with a left breast palpable mass. Histologic findings of the core-needle biopsy indicated breast cancer. The section revealed a squamoid tumor-cell proliferation with enlarged nuclei and eosinophilic cytoplasm among smaller intermediate cells and abundant cystic spaces containing secretory materials. The features were compatible with mucoepidermoid carcinoma in low-grade, confirmed by detecting the CRTC3–MAML2 fusion using reverse transcription polymerase chain reaction and direct sequencing. We only administered tamoxifen postoperatively without other adjuvant therapy because her tumor partially expressed hormonal receptors. No signs indicate a recurrence or metastasis in our over 3 year follow-up. The genetic analysis helps in definitively diagnosing breast mucoepidermoid carcinoma, and the treatment strategy should be considered based on the histologic findings.
Mucoepidermoid carcinoma is the most prevalent malignancy in the salivary gland and is sporadic in the breast. Here, we report a case of breast mucoepidermoid carcinoma with a rare CREB-regulated transcription coactivator 3-mastermind-like transcriptional coactivator 2 (CRTC3-MAML2) fusion. A 23-year-old female was admitted to our hospital with a left breast palpable mass. Histologic findings of the core-needle biopsy indicated breast cancer. The section revealed a squamoid tumor-cell proliferation with enlarged nuclei and eosinophilic cytoplasm among smaller intermediate cells and abundant cystic spaces containing secretory materials. The features were compatible with mucoepidermoid carcinoma in low-grade, confirmed by detecting the CRTC3-MAML2 fusion using reverse transcription polymerase chain reaction and direct sequencing. We only administered tamoxifen postoperatively without other adjuvant therapy because her tumor partially expressed hormonal receptors. No signs indicate a recurrence or metastasis in our over 3 year follow-up. The genetic analysis helps in definitively diagnosing breast mucoepidermoid carcinoma, and the treatment strategy should be considered based on the histologic findings.Mucoepidermoid carcinoma is the most prevalent malignancy in the salivary gland and is sporadic in the breast. Here, we report a case of breast mucoepidermoid carcinoma with a rare CREB-regulated transcription coactivator 3-mastermind-like transcriptional coactivator 2 (CRTC3-MAML2) fusion. A 23-year-old female was admitted to our hospital with a left breast palpable mass. Histologic findings of the core-needle biopsy indicated breast cancer. The section revealed a squamoid tumor-cell proliferation with enlarged nuclei and eosinophilic cytoplasm among smaller intermediate cells and abundant cystic spaces containing secretory materials. The features were compatible with mucoepidermoid carcinoma in low-grade, confirmed by detecting the CRTC3-MAML2 fusion using reverse transcription polymerase chain reaction and direct sequencing. We only administered tamoxifen postoperatively without other adjuvant therapy because her tumor partially expressed hormonal receptors. No signs indicate a recurrence or metastasis in our over 3 year follow-up. The genetic analysis helps in definitively diagnosing breast mucoepidermoid carcinoma, and the treatment strategy should be considered based on the histologic findings.
Author Yoshizumi, Tomoharu
Hisamatsu, Yuichi
Ijichi, Hideki
Oda, Yoshinao
Ueo, Hiroki
Yamamoto, Hidetaka
Kawaguchi, Kana
Shigechi, Tomoko
Kubo, Makoto
Kawaguchi, Kengo
Omori, Sachie
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Issue 4
Keywords fusion
Breast cancer
Mucoepidermoid carcinoma
Gene rearrangement
CRTC3–MAML2 fusion
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Snippet Mucoepidermoid carcinoma is the most prevalent malignancy in the salivary gland and is sporadic in the breast. Here, we report a case of breast mucoepidermoid...
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SubjectTerms Biopsy
Breast cancer
Breast carcinoma
Cancer therapies
Case report - Pathology
Case reports
Cell proliferation
Chemotherapy
Cyclic AMP response element-binding protein
Cytoplasm
Endocrine therapy
Exocrine glands
Genetic analysis
Histology
Leukocytes (eosinophilic)
Lymphatic system
Malignancy
Mammography
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Metastasis
Oncology
Polymerase chain reaction
Proteins
Radiation therapy
Reverse transcription
Salivary gland
Stains & staining
Surgical Oncology
Tumors
Ultrasonic imaging
Title Breast mucoepidermoid carcinoma with a rare CRTC3–MAML2 fusion
URI https://link.springer.com/article/10.1007/s13691-024-00713-2
https://www.ncbi.nlm.nih.gov/pubmed/39398906
https://www.proquest.com/docview/3114604563
https://www.proquest.com/docview/3116338276
Volume 13
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