Structure of the Fc fragment of human IgE bound to its high-affinity receptor FcεRIα

• Published in: Nature (London) Vol. 406; no. 6793; pp. 259 - 266
• Main Authors: Garman, Scott C., Wurzburg, Beth A., Tarchevskaya, Svetlana S., Kinet, Jean-Pierre, Jardetzky, Theodore S.
• Format: Journal Article
• Language: English
• Published: 20.07.2000
• Subjects: AFc receptors

The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, Fc epsilon RI. Crosslinking of Fc epsilon RI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response...