Cutting Edge: CXCR3 Escapes X Chromosome Inactivation in T Cells during Infection: Potential Implications for Sex Differences in Immune Responses

• Published in: The Journal of immunology (1950) Vol. 203; no. 4; pp. 789 - 794
• Main Authors: Oghumu, Steve, Varikuti, Sanjay, Stock, James C, Volpedo, Greta, Saljoughian, Noushin, Terrazas, Cesar A, Satoskar, Abhay R
• Format: Journal Article
• Language: English
• Published: United States 15.08.2019
• Subjects: Animals; Female; Infections - immunology; Male; Mice; Mice, Mutant Strains; Receptors, CXCR3 - genetics; Receptors, CXCR3 - immunology; Sex Characteristics; T-Lymphocyte Subsets - immunology; Th1 Cells - immunology; X Chromosome Inactivation - immunology

CXCR3, an X-linked gene, is subject to X chromosome inactivation (XCI), but it is unclear whether CXCR3 escapes XCI in immune cells. We determined whether CXCR3 escapes XCI in vivo, evaluated the contribution of allelic CXCR3 expression to the phenotypic properties of T cells during experimental inf...