Molecular characterization, biological function, tumor microenvironment association and clinical significance of m6A regulators in lung adenocarcinoma

• Published in: Briefings in bioinformatics Vol. 22; no. 4
• Main Authors: Li, Yin, Gu, Jie, Xu, Fengkai, Zhu, Qiaoliang, Chen, Yiwei, Ge, Di, Lu, Chunlai
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 20.07.2021; Oxford Publishing Limited (England)
• Subjects: Adenocarcinoma; Applications programs; Biological activity; Cancer; Chromosome 7; Clinical significance; Genetic diversity; Immune system; Immunotherapy; Lungs; Medical prognosis; Molecular modelling; Mutation; PD-L1 protein; Tumor microenvironment; Tumor-infiltrating lymphocytes; Tumors; A; web application; PD-L1 immunotherapy; lung adenocarcinoma; tumor microenvironment; m; prognosis

Abstract N6-methyladenosine (m6A) modification can regulate a variety of biological processes. However, the implications of m6A modification in lung adenocarcinoma (LUAD) remain largely unknown. Here, we systematically evaluated the m6A modification features in more than 2400 LUAD samples by analyzi...