A multipurpose eco-friendly separation-based approach for appraisal of a single-pill triple-action cramp relief combination; impurity separation, dissolution study and greenness/whiteness assessment

• Published in: Microchemical journal Vol. 198; p. 110062
• Main Authors: Ibrahim, Engy A., Saad, Samah S., Hegazy, Maha A., Fattah, Laila E. Abdel, Marzouk, Hoda M.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2024
• Subjects: Dissolution profiling; Greenness assessment; HPLC-UV; HPTLC-densitometry; Impurity profiling; Multi-component pharmaceutical formulation; Whiteness assessment; Impurity profiling; Greenness assessment; Multi-component pharmaceutical formulation; HPTLC-densitometry; Dissolution profiling; HPLC-UV; Whiteness assessment

[Display omitted] •A triple-action cramp relief over-the-counter pharmaceutical formulation of paracetamol, caffeine and pyrilamine maleate.•Novel eco-friendly HPTLC-densitometry and HPLC-UV methods for mixture analysis and purity assessment.•Successful applicability in assaying and quality control...