Evaluation of a novel lipid prodrug for intraocular drug delivery: effect of acyclovir diphosphate dimyristoylglycerol in a rabbit model with herpes simplex virus-1 retinitis
Acyclovir diphosphate dimyristoylglycerol is a lipid prodrug of acyclovir that forms liposomes and provides substantial activity against herpes simplex virus, acyclovir-resistant strains of herpes simplex virus, and human cytomegalovirus. We therefore tested this promising new drug in a rabbit model...
Saved in:
Published in | Retina (Philadelphia, Pa.) Vol. 17; no. 1; p. 57 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
1997
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Acyclovir diphosphate dimyristoylglycerol is a lipid prodrug of acyclovir that forms liposomes and provides substantial activity against herpes simplex virus, acyclovir-resistant strains of herpes simplex virus, and human cytomegalovirus. We therefore tested this promising new drug in a rabbit model of herpes simplex retinitis.
A total of 22 pigmented rabbits were pretreated with either acyclovir diphosphate dimyristoylglycerol, ganciclovir, acyclovir, or buffer. Retinae then were inoculated with herpes simplex virus-1 or buffer 1 week after the injection of drug. In another experiment we compared the effects of acyclovir diphosphate dimyristoylglycerol and acyclovir diphosphate dioleoylglycerol on the optical clarity of vitreous.
Animals injected intravitreally with acyclovir diphosphate dimyristoylglycerol showed retinitis that was less severe than that in animals injected with ganciclovir, acyclovir, and buffer; differences in grading scores of the retinitis between animals injected with acyclovir diphosphate dimyristoylglycerol and those injected with buffer were statistically significant (P = 0.0015). Vitreous and optical media became clear 4 days after acyclovir diphosphate dioleoylglycerol injection compared with 10 days after with acyclovir diphosphate dimyristoylglycerol injections.
Acyclovir diphosphate dimyristoylglycerol had prolonged antiviral activity against herpes simplex virus-1 retinitis in a rabbit model. This drug delivery system, modified to improve optical clarity, may allow long-acting intravitreal treatment of cytomegalovirus retinitis and other retinal diseases. |
---|---|
AbstractList | Acyclovir diphosphate dimyristoylglycerol is a lipid prodrug of acyclovir that forms liposomes and provides substantial activity against herpes simplex virus, acyclovir-resistant strains of herpes simplex virus, and human cytomegalovirus. We therefore tested this promising new drug in a rabbit model of herpes simplex retinitis.
A total of 22 pigmented rabbits were pretreated with either acyclovir diphosphate dimyristoylglycerol, ganciclovir, acyclovir, or buffer. Retinae then were inoculated with herpes simplex virus-1 or buffer 1 week after the injection of drug. In another experiment we compared the effects of acyclovir diphosphate dimyristoylglycerol and acyclovir diphosphate dioleoylglycerol on the optical clarity of vitreous.
Animals injected intravitreally with acyclovir diphosphate dimyristoylglycerol showed retinitis that was less severe than that in animals injected with ganciclovir, acyclovir, and buffer; differences in grading scores of the retinitis between animals injected with acyclovir diphosphate dimyristoylglycerol and those injected with buffer were statistically significant (P = 0.0015). Vitreous and optical media became clear 4 days after acyclovir diphosphate dioleoylglycerol injection compared with 10 days after with acyclovir diphosphate dimyristoylglycerol injections.
Acyclovir diphosphate dimyristoylglycerol had prolonged antiviral activity against herpes simplex virus-1 retinitis in a rabbit model. This drug delivery system, modified to improve optical clarity, may allow long-acting intravitreal treatment of cytomegalovirus retinitis and other retinal diseases. |
Author | Bergeron-Lynn, G Taskintuna, I Aldern, K A Freeman, W R Hostetler, K Y Flores-Aguilar, M Banker, A S |
Author_xml | – sequence: 1 givenname: I surname: Taskintuna fullname: Taskintuna, I organization: Department of Ophthalmology, University of California, San Diego, USA – sequence: 2 givenname: A S surname: Banker fullname: Banker, A S – sequence: 3 givenname: M surname: Flores-Aguilar fullname: Flores-Aguilar, M – sequence: 4 givenname: G surname: Bergeron-Lynn fullname: Bergeron-Lynn, G – sequence: 5 givenname: K A surname: Aldern fullname: Aldern, K A – sequence: 6 givenname: K Y surname: Hostetler fullname: Hostetler, K Y – sequence: 7 givenname: W R surname: Freeman fullname: Freeman, W R |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9051844$$D View this record in MEDLINE/PubMed |
BookMark | eNotUMtqwzAQ1CElTdN-QkE_4NayLVvqrYT0AYFeWugtSPIqUZEtI8lu_VP9xoo0C8vODLOzsFdo0bseEMIkvyM5b-7zVDVnRUY4b3KSWJaakAVa5UVDE6k-L9FVCF9JpYzRJVrynBJWVSv0u52EHUU0rsdOY4F7N4HF1gymxYN3rR8PWDuPTR-9cGq0wuOT2II1E_j5AYPWoOJpXc3KuskkixmOLgxHESHhbvYmRDfbg50VeGdTXLrlhZQm4s6lLPxt4hEfwQ8QcDDdYOEHp6QxZAR7iKY30YRrdKGFDXBznmv08bR937xku7fn183jLlMFpTGTNeW6lILWVckawetaFo1iZdNCwrmsKyJ0IxnVutDJWyumOefAGW1ZSaBYo9v_3GGUHbT7wZtO-Hl__lvxB6dQdf4 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1097/00006982-199701000-00011 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
ExternalDocumentID | 9051844 |
Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, U.S. Gov't, P.H.S Research Support, Non-U.S. Gov't Journal Article |
GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: GM24979 – fundername: NEI NIH HHS grantid: EY07366 – fundername: NIAID NIH HHS grantid: AI29161 |
GroupedDBID | --- .-D .GJ .Z2 01R 0R~ 123 1J1 2V- 40H 53G 5VS 71W 77Y 7O~ AAAAV AAAXR AAGIX AAHPQ AAIQE AAMOA AAMTA AAQKA AAQQT AARTV AASCR AASOK AAXQO AAYEP ABASU ABBUW ABDIG ABJNI ABOCM ABVCZ ABXRP ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFS ACILI ACLDA ACWDW ACWRI ACXJB ACXNZ ADFPA ADGGA ADHPY ADNKB AE3 AE6 AEETU AFDTB AFFNX AFMFY AFUWQ AGINI AHOMT AHPAA AHQNM AHVBC AIJEX AINUH AJIOK AJNWD AJNYG AJZMW AKULP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BOYCO BQLVK BS7 C45 CGR CS3 CUY CVF DIWNM DUNZO E.X EBS ECM EEVPB EIF EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FL- FW0 GNXGY GQDEL H0~ HLJTE HZ~ IKREB IKYAY IN~ IPNFZ JK3 JK8 K8S KD2 KMI L-C N9A NPM N~7 N~B N~M O9- OCUKA ODA OJAPA OL1 OLG OLH OLU OLV OLW OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OXXIT P-K R58 RIG RLZ S4R S4S ST3 TEORI TSPGW UCJ V2I W3M WOQ WOW X3V X3W YFH ZFV ZGI ZZMQN |
ID | FETCH-LOGICAL-c255t-b659f3ba564387a966b27c837de9660b641af7b85ff2f6596c8f999e985d831e2 |
ISSN | 0275-004X |
IngestDate | Wed Oct 16 00:50:38 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c255t-b659f3ba564387a966b27c837de9660b641af7b85ff2f6596c8f999e985d831e2 |
PMID | 9051844 |
ParticipantIDs | pubmed_primary_9051844 |
PublicationCentury | 1900 |
PublicationDate | 1997-00-00 |
PublicationDateYYYYMMDD | 1997-01-01 |
PublicationDate_xml | – year: 1997 text: 1997-00-00 |
PublicationDecade | 1990 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Retina (Philadelphia, Pa.) |
PublicationTitleAlternate | Retina |
PublicationYear | 1997 |
SSID | ssj0015885 |
Score | 1.6438398 |
Snippet | Acyclovir diphosphate dimyristoylglycerol is a lipid prodrug of acyclovir that forms liposomes and provides substantial activity against herpes simplex virus,... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 57 |
SubjectTerms | Acyclovir - analogs & derivatives Acyclovir - therapeutic use Animals Antiviral Agents - therapeutic use Disease Models, Animal Ganciclovir - therapeutic use Herpes Simplex - drug therapy Herpes Simplex - virology Liposomes Phosphatidylglycerols - therapeutic use Prodrugs - therapeutic use Rabbits Retinitis - drug therapy Retinitis - virology Simplexvirus - physiology Virus Replication |
Title | Evaluation of a novel lipid prodrug for intraocular drug delivery: effect of acyclovir diphosphate dimyristoylglycerol in a rabbit model with herpes simplex virus-1 retinitis |
URI | https://www.ncbi.nlm.nih.gov/pubmed/9051844 |
Volume | 17 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1fb9MwELc6EGgviH8T_-UH3qpMbdokLm8d2pgQmxDqpL5NtmOvEVkSNe1E-VB8J74Jdz43zbaCgJcostNz0vvpcne5-5mxt2KYgtHr6WAocQuzXhwGUqooiK0WSigbxRZ7h09O4-Oz4cdpNO10fraqlpYLta-_b-0r-R-twhjoFbtk_0GzjVAYgHPQLxxBw3D8Kx0fNlTd1OZYlFcm7-ZZlWHzf5nOl1QlmWEGt6SKUzeYmhzrMRzbE1V0OAF6pfPyKoOLsmpW1tUMHFE4v1w5AoJVfpGvtMHC9qyA1eZSqWxBe-lQPhf0X5m6W2dIOfytC5KWddDvYqMk1ijVbU_4Cw5KdHAxp4NkldWMCnc_y_1WfmIi669w_0vqXWtyvAey8PUg40329igv56YOxhdLkDi_lus9wC7TeVkEn1bksX_Y5DuIK7bJd5BZDJMoABBMr9nw5BZWySAT-_Wt9wTxD7uX9QhCDFyn1_dN9mT8W_CpLh1-kMlMEFnlHydv8Hf7mR22kwg0waeYTvKfuSLh9oxtHsmXmq1ZRbfd2y675yXeCIScQzR5yB74SIaPCZaPWMcUj9n9E1-r8YT92KCTl5ZL7tDJHTq5RycHdPIWOrkbXKPzHSdsup-vsclb2ORbsAniYC3CJnfY5IhNTtjkHpvcY5M32HzKzo4OJ--PA787SKAhDF4EKo5GdqBkBD61SCSE7SpMtBgkqUHGWRUP-9ImSkTWhhaujbWwEA2ZkYhSMeibcI_dKcrCPGM8Mn0dhalVA4vxuRADDc8HwU6iYgUe-nO2R__0eUUUMOdeBS9-N_GS7W6w-4rdtWBxzGtwXxfqjYPAL2Kjnj8 |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+a+novel+lipid+prodrug+for+intraocular+drug+delivery%3A+effect+of+acyclovir+diphosphate+dimyristoylglycerol+in+a+rabbit+model+with+herpes+simplex+virus-1+retinitis&rft.jtitle=Retina+%28Philadelphia%2C+Pa.%29&rft.au=Taskintuna%2C+I&rft.au=Banker%2C+A+S&rft.au=Flores-Aguilar%2C+M&rft.au=Bergeron-Lynn%2C+G&rft.date=1997-01-01&rft.issn=0275-004X&rft.volume=17&rft.issue=1&rft.spage=57&rft_id=info:doi/10.1097%2F00006982-199701000-00011&rft_id=info%3Apmid%2F9051844&rft_id=info%3Apmid%2F9051844&rft.externalDocID=9051844 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0275-004X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0275-004X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0275-004X&client=summon |