Simulation of electronic nicotine delivery systems (ENDS) aerosol dosimetry and nicotine pharmacokinetics

• Published in: Computational toxicology Vol. 31; p. 100322
• Main Authors: Schroeter, Jeffry, Asgharian, Bahman, Price, Owen, Parks, Aaron, Oldson, Darren, Fallica, Jonathan, Erives, Gladys, Li, Cissy, Rass, Olga, Harvanko, Arit, Peters, Kamau, Chemerynski, Susan
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2024
• Subjects: Aerosol; Dosimetry; Electronic nicotine delivery systems; Nicotine; Pharmacokinetics; Dosimetry; Pharmacokinetics; Electronic nicotine delivery systems; Aerosol; Nicotine

•ENDS aerosol constituent deposition varied by respiratory tract region and was consistently >80 %.•Lung deposition in the pulmonary region was considerably higher than in the tracheobronchial airways.•Plasma nicotine concentrations compared favorably with experimental data following ENDS use.•E-...