Secretion of urate in the proximal convoluted tubule of the rat

• Published in: American journal of physiology. Renal physiology Vol. 239; no. 4; pp. F383 - F387
• Main Authors: Weinman, E J, Sansom, S C, Steplock, D A, Sheth, A U, Knight, T F, Senekjian, H O
• Format: Journal Article
• Language: English
• Published: United States 01.10.1980
• Subjects: Animals; Chloromercuribenzoates - pharmacology; Kidney Tubules, Proximal - drug effects; Kidney Tubules, Proximal - metabolism; Male; Potassium - metabolism; Probenecid - pharmacology; Rats; Secretory Rate - drug effects; Uric Acid - metabolism

In order to examine the transepithelial secretory flux of urate in the rat proximal tubule, simultaneous perfusions of capillaries and lumens were performed. The capillary perfusate contained [2-14C]urate in concentrations of 0.305--2.94 mM. The secretory flux of urate increased as the concentration...