Genetic interactions and co-operating effects of non-HSA21 genes on the phenotypic variability in Down syndrome

• Published in: Gene reports Vol. 38; p. 102106
• Main Authors: Ganguly, Bani Bandana, Kadam, Nitin N.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.03.2025
• Subjects: Down syndrome; Down syndrome critical region and dogma; Epigenetic alterations; Genes for phenotypic variations; Interaction and synergism of genes; Trisomy 21; Abbreviation; NPC; All; Interaction and synergism of genes; Genes for phenotypic variations; HSA21; TMPD; aCGH; DS; Trisomy 21; DNMT; T21; ASD; AMKL; hiPSC; AVSD; DSCR; AD; BAC; MR; Down syndrome critical region and dogma; EGCG; VSD; Down syndrome; EOAD; Epigenetic alterations; CHD; HDAC

Trisomy 21 (T21) defines the complex characteristics of Down syndrome (DS). However, enormous variation has been documented in the multifarious features of the syndrome, regardless of full or partial T21 among individuals with DS. Individual variability exists in degree of manifestation for each sub...