An esterase-activatable nanoprodrug mitigates severe spinal cord injury via alleviating ferroptosis and reprogramming inflammatory microenvironment

• Published in: Nano today Vol. 56; p. 102229
• Main Authors: Liu, Jinggong, Chang, Yanzhou, Zhou, Wen, Rao, Siyuan, Wang, Hongshen, Lin, Rui, Hu, Weixiong, Chen, Shaohua, Su, Guoyi, Li, Yongjin, Lin, Yongpeng, Chen, Bolai, Chen, Tianfeng
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.06.2024
• Subjects: Biomaterials; Esterase-activatable; Nanomedicine; Spinal cord injury; Esterase-activatable; Spinal cord injury; Nanomedicine; Biomaterials

Spinal cord injury (SCI) is a devastating condition with limited efficacious treatment options. Recent research has revealed the potential of functional nanomedicines to inhibit ferroptosis and reduce inflammatory response, offering a promising therapeutic approach for SCI. Urolithin A (UA) exhibits...