Dual-emission ratiometric fluorometric platform using Cu@NCDs/eosin system for sensitive detection of metformin: Pharmacokinetic studies in normal and disease states

• Published in: Microchemical journal Vol. 209; p. 112789
• Main Authors: Jardan, Yousef A. Bin, El-Wekil, Mohamed M., Mostafa, Aya M., Barker, James, Ali, Almontaser Bellah H.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2025
• Subjects: Cu2+/NCDs; Eosin; Metformin; Pharmacokinetics; Ratiometric; Metformin; Pharmacokinetics; Cu2+/NCDs; Eosin; Ratiometric

[Display omitted] •New ratiometric fluorometric detection of metformin using Cu@NCDs/eosin dual-emission system.•Unique sensing mechanism based on simultaneous fluorescence quenching and enhancement.•Successful monitoring of metformin in healthy and renally impaired subjects.•Dual-response mechanism...