Relaxation of Androgens on Rat Thoracic Aorta: Testosterone Concentration Dependent Agonist/Antagonist l-Type Ca2+ Channel Activity, and 5β-Dihydrotestosterone Restricted to l-Type Ca2+ Channel Blockade

• Published in: Endocrinology (Philadelphia) Vol. 149; no. 5; pp. 2517 - 2526
• Main Authors: Montaño, Luis M., Calixto, Eduardo, Figueroa, Alejandra, Flores-Soto, Edgar, Carbajal, Verónica, Perusquía, Mercedes
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.05.2008; Endocrine Society
• Subjects: 17β-Estradiol; Agonists; Androgens; Aorta; Biological and medical sciences; Calcium (intracellular); Calcium antagonists; Calcium channels; Calcium channels (L-type); Calcium channels (voltage-gated); Calcium ions; Channel gating; Channels; Coronary vessels; Cyclic AMP; Dihydrotestosterone; Estrogens; Fundamental and applied biological sciences. Psychology; Low concentrations; Myocytes; Nifedipine; Noradrenaline; Norepinephrine; Potassium chloride; Sex hormones; Testosterone; Thorax; Vasodilation; Vertebrates: endocrinology; Agonist; Androgen; Rat; Rodentia; Artery; Thoracic aorta; Relaxation; Testosterone; Vertebrata; Dihydrotestosterone; Mammalia; Blood vessel; Animal; Circulatory system; Testicular hormone; Antagonist; Sex steroid hormone; L-type calcium channel

Androgen vasorelaxing action is a subject of recent interest. We investigated the involvement of l-type voltage-operated Ca2+ channels (L-VOCCs), K+ channels, intracellular Ca2+ concentration ([Ca2+]i), and cAMP in the vasorelaxing effect of testosterone and 5β-dihydrotestosterone (5β-DHT) on rat th...