Parenteral nutrition. Pharmaceutical problems of compatibility and stability
A typical All-in-One (AIO) parenteral nutrition mixture in a 3-litre polymeric infusion bag will consist of lipid emulsion, amino acids, glucose, electrolytes, trace elements and vitamins. This varied mixture of chemical entities provides the potential for a number of chemical and physicochemical in...
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Published in | Drug safety Vol. 5 Suppl 1; p. 101 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New Zealand
1990
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Abstract | A typical All-in-One (AIO) parenteral nutrition mixture in a 3-litre polymeric infusion bag will consist of lipid emulsion, amino acids, glucose, electrolytes, trace elements and vitamins. This varied mixture of chemical entities provides the potential for a number of chemical and physicochemical interactions that can compromise the clinical safety and efficacy of the product. The destabilisation of the lipid emulsion in the presence of electrolytes is a major problem. Although a predictive equation for the maximum concentrations of mono-, di- and trivalent ions causing instability has been proposed, it is too simplistic to be of significant value. The reasons for this are discussed as well as the stability implications of other additives to the parenteral nutrition mixture. |
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AbstractList | A typical All-in-One (AIO) parenteral nutrition mixture in a 3-litre polymeric infusion bag will consist of lipid emulsion, amino acids, glucose, electrolytes, trace elements and vitamins. This varied mixture of chemical entities provides the potential for a number of chemical and physicochemical interactions that can compromise the clinical safety and efficacy of the product. The destabilisation of the lipid emulsion in the presence of electrolytes is a major problem. Although a predictive equation for the maximum concentrations of mono-, di- and trivalent ions causing instability has been proposed, it is too simplistic to be of significant value. The reasons for this are discussed as well as the stability implications of other additives to the parenteral nutrition mixture. |
Author | Hall, S B Duffield, J R Evans, D A Williams, D R Cosslett, A G Barnett, M I |
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References | 6430966 - J Clin Hosp Pharm. 1984 Jun;9(2):75-85 2520328 - Nutrition. 1989 Sep-Oct;5(5):356-7 4205797 - Ann Surg. 1974 Apr;179(4):519-22 7274033 - Drug Intell Clin Pharm. 1981 Mar;15(3):184-93 3141645 - JPEN J Parenter Enteral Nutr. 1988 Sep-Oct;12(5):478-83 |
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Title | Parenteral nutrition. Pharmaceutical problems of compatibility and stability |
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