A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief

• Published in: Cell Vol. 157; no. 6; pp. 1393 - 1404
• Main Authors: Lee, Jun-Ho, Park, Chul-Kyu, Chen, Gang, Han, Qingjian, Xie, Rou-Gang, Liu, Tong, Ji, Ru-Rong, Lee, Seok-Yong
• Format: Journal Article
• Language: English
• Published: United States 05.06.2014
• Subjects: Amino Acid Sequence; Animals; Antibodies, Monoclonal - therapeutic use; HEK293 Cells; Humans; Inflammation - chemically induced; Inflammation - pathology; Mice; Models, Molecular; Molecular Sequence Data; NAV1.7 Voltage-Gated Sodium Channel - chemistry; NAV1.7 Voltage-Gated Sodium Channel - metabolism; Neurons - metabolism; Pain - drug therapy; Pruritus - drug therapy; Sequence Alignment; Spinal Cord - metabolism; Synaptic Transmission - drug effects; Voltage-Gated Sodium Channel Blockers - therapeutic use

Voltage-gated sodium (NaV) channels control the upstroke of the action potentials in excitable cells. Multiple studies have shown distinct roles of NaV channel subtypes in human physiology and diseases, but subtype-specific therapeutics are lacking and the current efforts have been limited to small...