Diagnosis of Retrograde Cricopharyngeus Dysfunction Using High Resolution Impedance Manometry and Comparison With Control Subjects

• Published in: Clinical gastroenterology and hepatology
• Main Authors: Raymenants, Karlien, Vulsteke, Friedel, Vanuytsel, Tim, Rommel, Nathalie, Baert, Filip, Delsupehe, Kathelijne, Bohyn, Alexandre, Tack, Jan, Arts, Joris
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.01.2025
• Subjects: Gastroenterology and Hepatology; High Resolution Impedance Manometry; Inability to Belch; Retrograde Cricopharyngeus Dysfunction; Upper Esophageal Sphincter; UES; R-CPD; CI; Inability to Belch; DCI; IQR; AP; HRiM; IRP4; IEM; RDC; High Resolution Impedance Manometry; GERD; BT; IRP0.2; Retrograde Cricopharyngeus Dysfunction; CC4.0; LES; ROC curve; Upper Esophageal Sphincter; receiver operating characteristics curve; Chicago Classification 4.0; interquartile range; integrated relaxation pressure 4 seconds; lower esophageal sphincter; distal contractile integral; botulinum toxin; integrated relaxation pressure 0.2 seconds; ineffective esophageal motility; absent peristalsis; confidence interval; gastroesophageal reflux disease; rapid drinking challenge

Retrograde cricopharyngeal dysfunction (R-CPD) or inability to belch has been linked to ineffective relaxation of the upper esophageal sphincter (UES) during gastroesophageal gas reflux, and botulinum toxin (BT) injection into the UES has demonstrated success in case series. However, the diagnosis i...