The Common Single Nucleotide Polymorphism E23K in KIR6.2 Sensitizes Pancreatic β-Cell ATP-Sensitive Potassium Channels Toward Activation Through Nucleoside Diphosphates

• Published in: Diabetes (New York, N.Y.) Vol. 51; no. suppl 3; pp. S363 - S367
• Main Authors: Schwanstecher, Christina, Neugebauer, Bettina, Schulz, Miriam, Schwanstecher, Mathias
• Format: Journal Article
• Language: English
• Published: American Diabetes Association 01.12.2002

E23K, a common polymorphism in the pore-forming subunit KIR6.2 of pancreatic β-cell ATP-sensitive K+ (KATP) channels, is functionally relevant and thus might play a major role in the pathophysiology of common type 2 diabetes. In this study, we show that in the simultaneous presence of activatory and...