The effect of blood flow modification on intra- and extracellular pH measured by 31P magnetic resonance spectroscopy in murine tumours

• Published in: British journal of cancer Vol. 72; no. 4; pp. 905 - 911
• Main Authors: MCCOY, C. L, PARKINS, C. S, CHAPLIN, D. J, GRIFFITHS, J. R, RODRIGUES, L. M, STUBBS, M
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.10.1995
• Subjects: Adenosine Triphosphate - metabolism; Animal tumors. Experimental tumors; Animals; Biological and medical sciences; Experimental tumors, general aspects; Flavonoids - pharmacology; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Medical sciences; Mice; Mice, Inbred CBA; Neoplasms, Experimental - blood supply; Neoplasms, Experimental - metabolism; Regional Blood Flow - drug effects; Tumors; Adenocarcinoma; Rodentia; Exploration; NMR spectrometry; Malignant tumor; Extracellular; Blood flow; Vertebrata; Mammalia; Mouse; Animal; pH; Hemodynamics; Intracellular

Intra- and extracellular pH (pHi and pHe) were measured simultaneously by 31P magnetic resonance spectroscopy (MRS) in CaNT tumours before and after blood flow modification. Before modification, pHi was 7.1 +/- 0.09 (n = 11) and pHe [measured with an MRS-visible extracellular marker, 3-aminopropyl p...