Distinct lactate metabolism between hepatocytes and myotubes revealed by live cell imaging with genetically encoded indicators

• Published in: Biochemical and biophysical research communications Vol. 694; p. 149416
• Main Authors: Horikoshi, Mina, Harada, Kazuki, Tsuno, Saki, Kitaguchi, Tetsuya, Hirai, Masami Yokota, Matsumoto, Mitsuharu, Terada, Shin, Tsuboi, Takashi
• Format: Journal Article
• Language: English
• Published: United States 29.01.2024
• Subjects: Adenosine Triphosphate - metabolism; Glucose - metabolism; Hepatocytes - metabolism; Lactic Acid; Muscle Fibers, Skeletal - metabolism; Pyruvates; Hepatocytes; Lactate metabolism; L6 cells; Cori cycle; Live cell imaging

The process of glycolysis breaks down glycogen stored in muscles, producing lactate through pyruvate to generate energy. Excess lactate is then released into the bloodstream. When lactate reaches the liver, it is converted to glucose, which muscles utilize as a substrate to generate ATP. Although th...