Positive allosteric modulation of native and recombinant GABAA receptors by hops prenylflavonoids

• Published in: European journal of pharmacology Vol. 852; pp. 34 - 41
• Main Authors: Benkherouf, Ali Y., Soini, Sanna L., Stompor, Monika, Uusi-Oukari, Mikko
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 05.06.2019
• Subjects: Allosteric modulation; Flavonoids; GABAA receptors; Humulus lupulus; Pharmacodynamics; Radioligand binding; Flavonoids; Pharmacodynamics; Allosteric modulation; Radioligand binding; Humulus lupulus; GABAA receptors

Hops are a major component of beer that is added during brewing. In addition to its wide range of bioactivity, it exhibits neuroactive properties as a sedative and sleeping aid. The compounds responsible for this activity are yet to be revealed and understood in terms of their pharmacological proper...