MODULATION OF IMPAIRED CHOLINESTERASE ACTIVITY IN EXPERIMENTAL DIABETES: EFFECT OF Gymnema montanum LEAF EXTRACT

• Published in: Journal of basic and clinical physiology and pharmacology Vol. 16; no. 1; pp. 17 - 36
• Main Authors: Ramkumar, Kunga Mohan, Latha, Muniappan, Ashokkumar, Natarajan, Pari, Leelavinothan, Ananthan, Rajendran
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 2005
• Subjects: Acetylcholinesterase - metabolism; Animals; Blood Glucose - metabolism; Brain - enzymology; Butyrylcholinesterase - metabolism; Cholinesterases - metabolism; Diabetes Mellitus, Experimental - enzymology; Diabetes Mellitus, Type 2 - chemically induced; Diabetes Mellitus, Type 2 - metabolism; Gymnema - chemistry; Insulin - blood; Lipid Peroxidation - drug effects; Male; Plant Extracts - pharmacology; Plant Leaves - chemistry; Rats; Rats, Wistar; Retina - enzymology; Thiobarbituric Acid Reactive Substances - metabolism

We reported that a leaf extract (GLEt) obtained from an anti-diabetic plant, Gymnema montanum, an endangered species endemic to India, has anti-peroxidative and antioxidant effects on diabetic brain tissue in rats. Here we examined the effect of the extract on the activity of reduced brain and retin...