MODULATION OF IMPAIRED CHOLINESTERASE ACTIVITY IN EXPERIMENTAL DIABETES: EFFECT OF Gymnema montanum LEAF EXTRACT

We reported that a leaf extract (GLEt) obtained from an anti-diabetic plant, Gymnema montanum, an endangered species endemic to India, has anti-peroxidative and antioxidant effects on diabetic brain tissue in rats. Here we examined the effect of the extract on the activity of reduced brain and retin...

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Published inJournal of basic and clinical physiology and pharmacology Vol. 16; no. 1; pp. 17 - 36
Main Authors Ramkumar, Kunga Mohan, Latha, Muniappan, Ashokkumar, Natarajan, Pari, Leelavinothan, Ananthan, Rajendran
Format Journal Article
LanguageEnglish
Published Germany De Gruyter 2005
Subjects
Acetylcholinesterase - metabolism
Animals
Blood Glucose - metabolism
Brain - enzymology
Butyrylcholinesterase - metabolism
Cholinesterases - metabolism
Diabetes Mellitus, Experimental - enzymology
Diabetes Mellitus, Type 2 - chemically induced
Diabetes Mellitus, Type 2 - metabolism
Gymnema - chemistry
Insulin - blood
Lipid Peroxidation - drug effects
Male
Plant Extracts - pharmacology
Plant Leaves - chemistry
Rats
Rats, Wistar
Retina - enzymology
Thiobarbituric Acid Reactive Substances - metabolism
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Abstract We reported that a leaf extract (GLEt) obtained from an anti-diabetic plant, Gymnema montanum, an endangered species endemic to India, has anti-peroxidative and antioxidant effects on diabetic brain tissue in rats. Here we examined the effect of the extract on the activity of reduced brain and retinal acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in streptozotocin (STZ)-induced diabetic male Wistar rats. Diabetic rats received GLEt orally (200 mg/kg bwt/d) for 12 wk, and changes in blood glucose, plasma insulin, the lipid peroxidation marker thiobarbituric acid-reactive substance (TBARS), and AChE and BChE activity were measured. The results confirmed prior reports that hyperglycemia significantly enhances TBARS levels in brain and retinal tissue and decreases AChE and BChE activity. Treatment with GLEt significantly reversed the impairment in enzymatic activity in addition to reducing the level of TBARS, suggesting that GLEt protects against the adverse effect of lipid peroxidation on brain and retinal cholinesterases. We suggest that GLEt could be useful for preventing the cholinergic neural and retinal complications of hyperglycemia in diabetes.
AbstractList We reported that a leaf extract (GLEt) obtained from an anti-diabetic plant, Gymnema montanum, an endangered species endemic to India, has anti-peroxidative and antioxidant effects on diabetic brain tissue in rats. Here we examined the effect of the extract on the activity of reduced brain and retinal acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in streptozotocin (STZ)-induced diabetic male Wistar rats. Diabetic rats received GLEt orally (200 mg/kg bwt/d) for 12 wk, and changes in blood glucose, plasma insulin, the lipid peroxidation marker thiobarbituric acid-reactive substance (TBARS), and AChE and BChE activity were measured. The results confirmed prior reports that hyperglycemia significantly enhances TBARS levels in brain and retinal tissue and decreases AChE and BChE activity. Treatment with GLEt significantly reversed the impairment in enzymatic activity in addition to reducing the level of TBARS, suggesting that GLEt protects against the adverse effect of lipid peroxidation on brain and retinal cholinesterases. We suggest that GLEt could be useful for preventing the cholinergic neural and retinal complications of hyperglycemia in diabetes.
Author Ramkumar, Kunga Mohan
Ananthan, Rajendran
Latha, Muniappan
Pari, Leelavinothan
Ashokkumar, Natarajan
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Snippet We reported that a leaf extract (GLEt) obtained from an anti-diabetic plant, Gymnema montanum, an endangered species endemic to India, has anti-peroxidative...
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SubjectTerms Acetylcholinesterase - metabolism
Animals
Blood Glucose - metabolism
Brain - enzymology
Butyrylcholinesterase - metabolism
Cholinesterases - metabolism
Diabetes Mellitus, Experimental - enzymology
Diabetes Mellitus, Type 2 - chemically induced
Diabetes Mellitus, Type 2 - metabolism
Gymnema - chemistry
Insulin - blood
Lipid Peroxidation - drug effects
Male
Plant Extracts - pharmacology
Plant Leaves - chemistry
Rats
Rats, Wistar
Retina - enzymology
Thiobarbituric Acid Reactive Substances - metabolism
Title MODULATION OF IMPAIRED CHOLINESTERASE ACTIVITY IN EXPERIMENTAL DIABETES: EFFECT OF Gymnema montanum LEAF EXTRACT
URI https://api.istex.fr/ark:/67375/QT4-T8XNHQSR-H/fulltext.pdf
https://www.ncbi.nlm.nih.gov/pubmed/16187484
Volume 16
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