Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles

• Published in: Doklady. Biochemistry and biophysics Vol. 516; no. 1; pp. 111 - 114
• Main Authors: Filimonova, M. V., Kolmanovich, D. D., Tikhonowski, G. V., Petrunya, D. S., Kotelnikova, P. A., Shitova, A. A., Soldatova, O. V., Filimonov, A. S., Rybachuk, V. A., Kosachenko, A. O., Nikolaev, K. A., Demyashkin, G. A., Popov, A. A., Savinov, M. S., Popov, A. L., Zelepukin, I. V., Lipengolts, A. A., Shpakova, K. E., Kabashin, A. V., Koryakin, S. N., Deyev, S. M., Zavestovskaya, I. N.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.06.2024; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Carcinoma, Ehrlich Tumor - drug therapy; Carcinoma, Ehrlich Tumor - pathology; Carcinoma, Ehrlich Tumor - radiotherapy; Cell death; Cell Line, Tumor; Gold; Gold - chemistry; Gold - pharmacology; Life Sciences; Metal Nanoparticles - chemistry; Metal Nanoparticles - therapeutic use; Mice; Molecular Biology; Nanoparticles; Polyethylene Glycols - chemistry; Proton Therapy - methods; Tumor cells; Tumors; gold; proton therapy; nanoparticles; radiosensitizers; tumor therapy
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S1607672924700819

Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.